Caspase-4 is an inflammatory caspase; however, its mechanism of activation is poorly
understood. In this study, we demonstrate that Td92, a surface protein of the periodontal …

Periodontitis, a common infectious disease, is initiated by various gram-negative bacteria
and characterized by the destruction of the periodontal tissue. Here, we investigated the role …

Objective Implication of human caspase-4 in periodontitis and in sensing periodontal
pathogens by gingival epithelial cells (GECs) is unclear. This study aimed to determine …

Objective This study investigated the main mechanism and role of caspase-11/4 as a pattern
recognition receptor (PRR) in periodontitis through caspase-11 inhibition. Design Clinical …

Abstract Background and Objectives Periodontitis is a chronic inflammatory disease linked
to pyroptosis, an inflammatory cell death process. Macrophages are essential for …

The study was to investigate the effect of canonical and noncanonical pyroptosis in apical
periodontitis. Proteins' profiles of human apical periodontitis tissue were analyzed by label …

Objective The aim of this study was to analyze whether periodontopathogens induced
inflammatory cell death and the release of diverse endogenous danger molecules in THP-1 …

Background/purpose Pyroptosis is a form of programmed cell death dependent on the
activation of caspase-1. Porphyromonas gingivalis (P. gingivalis) is a major pathogenic …

Porphyromonas gingivalis is an oral bacterium that causes pathology in a number of dental
infections that are associated with increased fibroblast cell death. Studies presented here …

Aim A highly‐regulated form of programmed cell death is apoptosis, and its perturbation has
been associated with periodontal disease. Caspase‐3 is one of the key executioners of …