Background Excessive risk taking is a characteristic trait of several psychiatric conditions,
including substance use disorders. High risk-taking (HiR) rats self-administer more cocaine …

Patients with psychiatric disorders, such as gambling and substance use, tend to exhibit
maladaptive decision-making. In this study, we assessed individual differences in risk-taking …

Substance use is strongly associated with impaired decision making, with cocaine use
particularly linked to elevated risky and impulsive choice. It is not clear, however, whether …

Poor decision-making is a core problem in psychiatric disorders such as pathological
gambling and substance abuse. Both trait and environmental factors are considerably …

We developed a behavioral task in rats to assess the influence of risk of punishment on
decision making. Male Long–Evans rats were given choices between pressing a lever to …

The identification of behavioral traits that could predict an individual's susceptibility to
engage in cocaine addiction is relevant for understanding and preventing this disorder, but …

Background: Substance use disorder emerges in a small proportion of drug users and has
the characteristics of a chronic relapsing pathology. Aims: Our study aimed to demonstrate …

Rationale Drug addiction is a multifactorial disorder resulting from an interaction between
genetic and environmental factors, and negative and positive environmental conditions may …

Alcohol has been reported to modulate the reinforcing and aversive properties of cocaine.
Given these effects, the present study examined whether this interaction could be extended …

Human and animal laboratory studies show that females and males respond differently to
drugs and that drug administration during adolescence leads to different behavioral effects …