Abstract Poly (ADP-ribose) polymerase (PARP) activation has been implicated in the
pathogenesis of acute and chronic myocardial dysfunction and heart failure. The goal of the …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in regulating genome
stability, cell cycle progression, and cell survival. However, overactivation of PARP has been …

Overactivation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) contributes to
the development of cell dysfunction and tissue injury in various pathophysiological …

Objectives: We investigated the effects of a novel ultrapotent poly (adenosine diphosphate-
ribose) polymerase (PARP) inhibitor, PJ34, on cardiac and endothelial dysfunction in a rat …

Objective: Oxidant stress-induced activation of poly (ADP-ribose) polymerase (PARP) plays
a role in the pathogenesis of various cardiovascular diseases. We have now investigated …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …

Diabetic cardiomyopathy is characterized by structural alterations such as cardiomyocyte
hypertrophy, necrosis and focal fibrosis. Hyperglycemia-induced oxidative damage may play …

Free radical and oxidant production in cardiac myocytes during ischemia/reperfusion,
cardiomyopathy, cardiotoxic drug exposure and ageing leads to DNA strand-breakage …

The activation of poly (ADP-ribose) polymerase (PARP) is now considered a final common
effector in various types of tissue injury including systemic inflammation, circulatory shock …

Reactive free radical and oxidant production leads to DNA damage during myocardial
Ischemia/reperfusion. Consequent overactivation of poly (ADP-ribose) polymerase (PARP) …