Abstract See Lenck-Santini (doi: 10.1093/awx205) for a scientific commentary on this article.
Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution …

Purpose: Focal seizures are thought to reflect simultaneous activation of a large population
of neurons within a discrete region of pathologic brain. Resective surgery targeting this focus …

Temporal lobe seizures in humans correlate with stereotyped electrophysiological patterns
that can be reproduced in animal models to study the cellular and network changes …

Analyzing neuronal activity during human seizures is pivotal to understanding mechanisms
of seizure onset and propagation. These analyses, however, invariably using extracellular …

The role of inhibitory neuronal activity in the transition to seizure is unclear. On the one
hand, seizures are associated with excessive neuronal activity that can spread across the …

The neurophysiological patterns that correlate with partial (focal) seizures are well defined in
humans by standard electroencephalogram (EEG) and presurgical depth electrode …

Epileptic networks are characterized by two outputs: brief interictal spikes and rarer, more
prolonged seizures. Although either output state is readily modeled in silico and induced …

The transition from brief bursts of synchronous population activity characteristic of interictal
epileptiform discharges (IEDs) to more prolonged epochs of population activity characteristic …

Objective To better understand the mechanisms that lead to the sudden and unexpected
occurrence of seizures, with the neuronal correlate being abnormally synchronous …

Multiple studies have observed heterogeneous neuronal firing patterns as a local network
transitions to spontaneous seizures. We demonstrated that separately examining …