Purpose Epilepsy is a disease of neurological character. Approximately one third of epileptic
patients demonstrate a drug-resistant phenotype, which is associated with the development …

Epilepsy is a common neurological disorder. About one-third of epileptic patients
demonstrate multidrug resistance (MDR) phenotype and develop drug-resistant epilepsy …

One-third of all individuals with epilepsy are resistant to antiepileptic drug (AED) treatment.
Antiepileptic treatment response has been suggested to be modulated by genetic …

Recent data indicate the possibility of P-glycoprotein involvement in drug resistance in
patients diagnosed with epilepsia. It was demonstrated that P-glycoprotein is expressed in …

Despite considerable progress in the pharmacotherapy of epilepsy, more than 30% of
patients are reported to be resistant to antiepileptic drugs. Multidrug resistance 1 (MDR1) …

Introduction A mutation at nucleotide position 3435 in exon 26 of the multidrug resistance 1
(MDR1) gene is the most frequently studied polymorphism in relation to multidrug …

Purpose: P‐glycoprotein (P‐gp) has been implicated in the causation of refractory epilepsy.
The expression and efflux efficiency of P‐gp is influenced by a polymorphism (C3435T) in …

Antiepileptic drug (AED) treatment in epilepsy is often compromised by the unpredictability
of efficacy and inter-individual variability among patients, which at least in part is the result of …

The association between the MDR1 gene C3435T polymorphism and childhood intractable
epilepsy remains controversial. In this study, we performed a meta-analysis to clarify this …

Sažetak U ovom pismu se komentira rad Sills GJ i suradnika, koji nisu pronašli povezanost
C3435T polimorfizma MDR1 gena i kliničkog odgovara na farmakoterapiju antiepilepticima …