The development of therapies to eliminate the latent HIV-1 reservoir is hampered by our
incomplete understanding of the biomolecular mechanism governing HIV-1 latency. To …

HIV-1 infection is characterized by varying degrees of chronic immune activation and
disruption of T-cell homeostasis, which impact the rate of disease progression. A deeper …

Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate
the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during …

The latent reservoir of HIV-1 in resting CD4+ T cells is a major barrier to cure. It is unclear
whether the latent reservoir resides principally in particular subsets of CD4+ T cells, a …

Background Eradication of HIV-1 from an infected individual cannot be achieved by current
drug regimens. Viral reservoirs established early during the infection remain unaffected by …

Highlights•Memory CD4+ T cells with latently integrated proviruses are a major barrier to
curing HIV infection.•Proviral integration within genes involved in cancer may contribute to …

Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral
load to clinically undetectable levels, viral rebound inevitably occurs once ART is …

Although antiretroviral therapy (ART) is highly effective at suppressing HIV-1 replication, the
virus persists as a latent reservoir in resting CD4+ T cells during therapy. This reservoir …

HIV infection is not curable with current antiretroviral therapy (ART) because a small fraction
of CD4+ T cells infected prior to ART initiation persists. Understanding the nature of this …

Antiretroviral therapy controls, but does not cure, HIV-1 infection due to a reservoir of rare
CD4+ T cells harboring latent proviruses. Little is known about the transcriptional program of …