Recent research has emphasized the notion that human immunodeficiency virus type 1 (HIV-
1) latency is controlled by a restrictive histone code at, or DNA methylation of, the integrated …

Human immunodeficiency virus type 1 (HIV-1) infection is a chronic condition, where viral
DNA integrates into the genome. Latently infected cells form a persistent, heterogeneous …

Despite antiretroviral therapy, HIV-1 persists in memory CD4+ T cells, creating a barrier to
cure. The majority of HIV-1 proviruses are defective and considered clinically irrelevant …

Future HIV-1 curative therapies require a thorough understanding of the distribution of
genetically-intact HIV-1 within T-cell subsets during antiretroviral therapy (ART) and the …

The introduction of highly active antiretroviral therapy (HAART) has been an important
breakthrough in the treatment of HIV‐1 infection and has also a powerful tool to upset the …

Abstract Memory CD4+ T cells (mCD4s) containing integrated HIV DNA are considered the
main barrier to a cure for HIV infection. Here, we analyzed HIV DNA reservoirs in antigen …

HIV-1 can establish a state of latent infection at the level of individual T cells. Latently
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …

The presence of an extremely stable latent reservoir of HIV-1 is the major obstacle to
eradication, despite effective antiretroviral therapy (ART). Recent studies have shown that …

Background The latent human immunodeficiency virus type 1 (HIV-1) reservoir represents a
major barrier to a cure. Based on the levels of HIV-1 DNA in naive (TN) vs resting memory …

Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus
(HIV) replication to undetectable levels but cannot fully eradicate the virus because a small …