BACKGROUND & AIMS:: Duodenal bicarbonate secretion is in part mediated by an apical
Cl−/HCO3− exchanger of unknown molecular nature. The recently discovered dra (down …

BACKGROUND & AIMS: The current model of duodenal HCO3− secretion proposes that
basal secretion results from Cl−/HCO3− exchange, whereas cyclic adenosine …

Mutations in human DRA cause congenital chloride diarrhea, thereby raising the possibility
that it functions as a Cl−/HCO 3− exchanger. To test this hypothesis we cloned a cDNA …

Electroneutral NaCl absorption in the intestine is mediated by parallel Na+/H+ and Cl−/HCO
3− exchange. Mutations in the down-regulated in adenoma (DRA) gene cause congenital …

Two distinct Cl/anion exchange activities (Cl/HCO3and Cl/OH) identified in apical
membranes of rat distal colon are distributed in cell type-specific patterns …

BACKGROUND & AIMS: Electroneutral NaCl absorption across small intestine contributes
importantly to systemic fluid balance. Disturbances in this process occur in both obstructive …

DRA (down regulated in adenoma) is an intestinal anion exchanger, acting in parallel with
NHE3 to facilitate ileal and colonic NaCl absorption. Furthermore it is involved in small …

Basal HCO3− secretion across the duodenum has been shown in several species to
principally involve the activity of apical membrane Cl−/HCO3− exchanger (s). To investigate …

Background & Aims: HCO3− supply to the enterocyte is rate limiting for duodenal HCO3−
secretion (JHCO3−). This study defines the molecular nature of the major HCO3− uptake …

The Na/H exchanger 3 (NHE3) and the Cl/HCO 3 exchanger down-regulated in adenoma
(DRA) together facilitate intestinal electroneutral NaCl absorption. Elevated Ca 2+ i inhibits …