COOH-terminal cytoplasmic tails of chloride/bicarbonate anion exchangers (AE) bind
cytosolic carbonic anhydrase II (CAII) to form a bicarbonate transport metabolon, a …

Background & Aims: Adenosine 3', 5'-cyclic monophosphate (cAMP)-stimulated anion
secretion across the duodenal epithelium requires the cystic fibrosis transmembrane …

The molecular identity of the apical HCO3--secreting transporter in gastric mucous cells
remains unknown despite its essential role in preventing injury and ulcer by gastric acid …

The colon is believed to absorb NaCl via the coupled operation of apical Na/H exchanger-3
(NHE3) and Cl/HCO3 exchanger SLC26A3 (DRA). Efficient coupling requires that NHE3 …

Active transcellular oxalate transport in the mammalian intestine contributes to the
homeostasis of this important lithogenic anion. Several members of the Slc26a gene family …

The mechanism of the pancreatic ductal HCO 3− secretion defect in cystic fibrosis (CF) is not
well defined. However, a lack of apical Cl−/HCO 3− exchange may exist in CF. To test this …

The role of Slc26a6 (PAT1) on apical Cl−/HCO3− exchange and bicarbonate secretion in
pancreatic duct cells was investigated using Slc26a6 null and wild-type (WT) mice. Apical …

Downregulated in adenoma (DRA), also referred to as SLC26A3, is an intestinal anion
transporter essential for intestinal chloride absorption. Mutations in DRA result in congenital …

Anion secretion by colonic epithelium is dependent on apical CFTR-mediated anion
conductance and basolateral ion transport. In many tissues, the NKCC1 Na+-K+-2Cl …

The pathogenesis of diarrhea in intestinal inflammatory states is a multifactorial process
involving the effects of inflammatory mediators on epithelial transport function. The effect of …