BRCA1-associated breast and ovarian cancer risks can be modified by common genetic
variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of …

Germline mutations in BRCA1 and BRCA2 confer high risks of female breast and ovarian
cancer. However, there is strong evidence that these risks are modified by other factors …

Background Genome-wide association studies (GWAS) have identified 94 common single-
nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 …

Background BRCA1 or BRCA2 mutations confer increased risks of breast and ovarian
cancer, but risks have been found to vary across studies and populations. Methods We …

Common genetic variants contribute to the observed variation in breast cancer risk for
BRCA2 mutation carriers; those known to date have all been found through population …

Background: BRCA1 is a tumour suppressor with pleiotropic actions. Germline mutations in
BRCA1 are responsible for a large proportion of breast–ovarian cancer families. Several …

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this
risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 …

Previous studies have reported variation in BRCA1 breast and ovarian cancer risks with
mutation position, suggesting that mutations toward the 3′ end of the gene are associated …

Background Clinical classification of rare sequence changes identified in the breast cancer
susceptibility genes BRCA1 and BRCA2 is essential for appropriate genetic counselling of …

Purpose We assessed the associations between population-based polygenic risk scores
(PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and …