[HTML][HTML] Photoreactivity and phototoxicity of experimentally photodegraded hair melanosomes from individuals of different skin phototypes

K Mokrzyński, M Sarna, T Sarna - Journal of Photochemistry and …, 2023 - Elsevier
Even though melanin is commonly viewed as natural photoprotectant, the pigment
demonstrates residual photoreactivity, which under certain conditions could contribute to …

[HTML][HTML] Photoreactivity of hair melanin from different skin phototypes—contribution of melanin subunits to the pigments photoreactive properties

K Mokrzynski, S Ito, K Wakamatsu… - International Journal of …, 2021 - mdpi.com
Photoreactivity of melanin has become a major focus of research due to the postulated
involvement of the pigment in UVA-induced melanoma. However, most of the hitherto …

Comparable Photoreactivity of Hair Melanosomes, Eu‐ and Pheomelanins at Low Concentrations: Low Melanin a Risk Factor for UVA Damage and Melanoma?

RM Haywood, M Lee, C Andrady - Photochemistry and …, 2008 - Wiley Online Library
Melanin is known to be photoreactive and photoprotective, but its function in skin in vivo is
still debated. Data is lacking of the effects of UVA irradiation on human skin melanosomes of …

Photoaging of retinal pigment epithelial melanosomes: the effect of photobleaching on morphology and reactivity of the pigment granules

A Zadlo, G Szewczyk, M Sarna, A Kozinska… - Free Radical Biology …, 2016 - Elsevier
To elucidate the mechanism of age-related changes in antioxidant and photoprotective
properties of human retinal pigment epithelium (RPE) melanosomes, the effect of in vitro …

The role of hydrogen peroxide and singlet oxygen in the photodegradation of melanin

A Żądto, S Ito, M Sarna, K Wakamatsu… - Photochemical & …, 2020 - Springer
When aging, melanin in human retinal pigment epithelium (RPE) undergoes oxidative
modifications, which increase its photoreactivity and reduce its antioxidant capacity …

UVA‐induced oxidative degradation of melanins: fission of indole moiety in eumelanin and conversion to benzothiazole moiety in pheomelanin

K Wakamatsu, Y Nakanishi, N Miyazaki… - Pigment cell & …, 2012 - Wiley Online Library
Eumelanin is photoprotective while pheomelanin is phototoxic to pigmented tissues.
Ultraviolet A (UVA)‐induced tanning seems to result from the photooxidation of pre‐existing …

The effect of aging and antioxidants on photoreactivity and phototoxicity of human melanosomes: An in vitro study

MM Olchawa, GM Szewczyk, AC Zadlo… - Pigment cell & …, 2021 - Wiley Online Library
Aging may significantly modify antioxidant and photoprotective properties of melanin in
retinal pigment epithelium (RPE). Here, photoreactivity of melanosomes (MS), isolated from …

Effect of untreated and photobleached bovine RPE melanosomes on the photoinduced peroxidation of lipids

A Zadlo, JM Burke, T Sarna - Photochemical & Photobiological Sciences, 2009 - Springer
Melanin is usually considered a photoprotective pigment and antioxidant agent, but it is
unclear how melanosomes protect pigmented cells against oxidative stress induced by light …

The effect of oxidative degradation of Dopa‐melanin on its basic physicochemical properties and photoreactivity

K Mokrzyński, A Żądło, G Szewczyk… - Pigment Cell & …, 2024 - Wiley Online Library
Melanin, particularly eumelanin, is commonly viewed as an efficient antioxidant and
photoprotective pigment. Nonetheless, the ability of melanin to photogenerate reactive …

Photobleaching of pheomelanin increases its phototoxic potential: Physicochemical studies of synthetic pheomelanin subjected to aerobic photolysis

A Zadlo, G Szewczyk, M Sarna… - Pigment cell & …, 2019 - Wiley Online Library
Although melanin is a photoprotective pigment, its elevated photochemical reactivity could
lead to various phototoxic processes. Photoreactivity of synthetic pheomelanin, derived from …