B-lymphocyte differentiation is one of the best understood developmental pathways in the
hematopoietic system. Our understanding of the developmental trajectories linking the …

Although B lymphopoiesis is one of the best-defined paradigms in cell differentiation, our
knowledge of the regulatory mechanisms underlying its earliest processes, in which …

Early B cell development in the bone marrow ensures the replenishment of the peripheral B
cell pool. Immature B cells continuously develop from hematopoietic stem cells, in a process …

Genetic networks that regulate B lymphopoiesis : Current Opinion in Hematology Genetic
networks that regulate B lymphopoiesis : Current Opinion in Hematology Log in or Register …

Early B-cell development is an ordered and highly regulated process with alternating
phases of cell proliferation and differentiation leading to B cells with the ability to recognize …

Powerful techniques—including gene targeting, genomic and proteomic analyses—are
allowing a more complete understanding of the transcription factors that drive B-cell …

The progression of hematopoietic stem cells (HSCs) to the B lymphocyte lineage requires
that uncommitted progenitors successfully negotiate the transition from multipotency to …

The generation of B cells is the result of several cell lineage choices, cell commitment and
differentiation. These cellular transitions take place in a stepwise manner and are regulated …

The maturation of B‐lymphoid cells from hematopoietic stem cells in the bone marrow is a
complex process under control of interplay between extrinsic and intrinsic factors. In addition …

Despite the tremendous diversity of the cells of the hematopoietic system, they are all
derived from common precursor cells that are generated in the fetus and persist into adult …