Affinity maturation and terminal differentiation of B cells via the germinal center reaction is a
complex multistep process controlled by transcription factors that induce or suppress large …

The latest scientific findings in the field of cancer research are redefining our understanding
of the molecular and cellular basis of the disease, moving the emphasis toward the study of …

In adult mammals, bone marrow pluripotent hematopoietic stem cells generate B lymphoid‐
specified progeny that progress through a series of well‐characterized stages before …

Experimental perturbation of signaling or transcription factor networks has been used to
study the developmental potential of lymphoid progenitors, lineage-committed precursors …

To understand the developmental trajectories in early lymphocyte differentiation, we
identified differentially expressed surface markers on lineage-negative lymphoid progenitors …

Integration of external signals and B-lymphoid transcription factor activities organise B cell
lineage commitment through alternating cycles of proliferation and differentiation, producing …

We describe here three CD19− B cell precursor populations in mouse bone marrow
identified using 12-color flow cytometry. Cell transfer experiments indicate lineage potentials …

UMAN B-lymphocyte development, activation, prolif-H eration, and differentiation are
elaborately regulated at multiple levels by a complex interplay of specific cell types and …

The phenotype of B lymphocytes at various stages of differentiation is, in part, controlled at
the transcriptional level. Recently, a number of B-cell lineage and stage-specific …

B-cell development is characterized by the progressive maturation of hematopoietic stem
cells through several stages to ultimately give rise to the mature B-cell pool that has been …