The mechanisms that drive normal B cell differentiation and activation are frequently
subverted by B cell lymphomas for their unlimited growth and survival. B cells are …

In an attempt to characterize early B cell development including the commitment of
progenitor cells to the B cell lineage, we generated and compared genomewide gene …

Genes encoding B lineage–restricted transcription factors are frequently mutated in B-
lymphoid leukemias, suggesting a close link between normal and malignant B-cell …

The subdivision of bone marrow (BM) with surface markers and reporter systems and the
use of multiple culture and transplantation assays to assess differentiation potential have led …

We have characterized several stages of normal human B cell development in adult bone
marrow by gene expression profiling of hemopoietic stem cells, early B (EB), pro-B, pre-B …

Altered B‐cell homeostasis underlies a wide range of pathologies, from cancers to
autoimmunity and immunodeficiency. The molecular safeguards against those disorders …

The lymphoid tissues, including both the B and T cell lineages, are characterized by a
unique level of biological complexity due to the anatomical organization of functionally …

Studies over the last decade uncovered overlapping niches for hematopoietic stem cells
(HSC s), multipotent progenitor cells, common lymphoid progenitors, and early B cell …

Acute lymphoblastic leukemia (ALL) is the most frequent malignancy of childhood.
Substantial progress on understanding the cell hierarchy within ALL bone marrow (BM) has …