Hematopoiesis is regulated by signals from the microenvironment, transcription factor
networks, and changes of the epigenetic landscape. Transcription factors interact with and …

The generation of B-lymphocytes from hematopoietic stem cells is controlled by multiple
transcription factors regulating distinct developmental aspects. Ikaros and PU. 1 act in …

Despite much progress in elucidating the cellular stages of B-cell development, the use of
diverse phenotypic criteria and terminologies has hampered cross-reference between …

B cell lymphomas comprise a heterogeneous group of genetically, biologically, and clinically
distinct neoplasms that, in most cases, originate from the clonal expansion of B cells in the …

Transcription factor doses are of importance for normal and malignant B-lymphocyte
development; however, the understanding of underlying mechanisms and functional …

The repertoire of B cells secreting antibodies with unique antigen-binding specificities is
produced at two stages: a primary B-cell repertoire is formed in the bone marrow through …

Human lymphopoiesis is a dynamic lifelong process that starts in utero 6 weeks
postconception. Although fetal B-lymphopoiesis remains poorly defined, it is key to …

It is now widely accepted that lymphomagenesis is a multistep transformation process. A
number of genetic changes and environmental and infectious factors contributing to the …

Publisher Summary This chapter provides a current understanding of hematolymphoid
development from rare hematopoietic stem cells that give rise to progenitor subsets that …