Models of hematopoiesis often depict lymphocyte production as a uniform process in which
a homogenous population of hematopoietic stem cells (HSCs) generates progenitors from …

The initial phases of B cell development depend on interactions between the cell surface
molecules and secreted products of stromal cells with their receptor-ligand partners on …

Transcription factors influence B cell differentiation by regulating the expression of
numerous lineage-specific genes. Recent studies have identified factors that regulate …

Studies of normal blood cell development and malignant transformation of hematopoietic
cells have shown that the correctly regulated expression of stage-and lineage-specific …

Signalling through the B‐cell antigen receptor (BCR) is required throughout B‐cell
development and peripheral maturation. Targeted disruption of BCR components or …

B lymphocytes differentiate from hematopoietic stem cells through a series of distinct stages.
Early B cell development proceeds in bone marrow until immature B cells migrate out to …

B cell development is a process tightly regulated by the orchestrated signaling of cytokine
receptors, the pre-B cell receptor (BCR) and the B cell receptor (BCR). It commences with …

The developmental program that commits a hematopoietic stem cell to the B lymphocyte
lineage employs transcriptional regulators to enable the assembly of an antigen receptor …

B cells differentiate from pluripotent hematopoietic stem cells (pHSCs) in a series of distinct
stages. During early embryonic development, pHSCs migrate into the fetal liver, where they …

Fluorescence‐activated cell sorting (FACS)–purified pro‐B cells from fetal liver and adult
bone marrow generate B cells with distinct phenotypes: fetal cells generate few IgDhigh B …