[HTML][HTML] ACE2, much more than just a receptor for SARS-COV-2

L Samavati, BD Uhal - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
The rapidly evolving pandemic of severe acute respiratory syndrome coronavirus (SARS-
CoV-2) infection worldwide cost many lives. The angiotensin converting enzyme-2 (ACE-2) …

[HTML][HTML] Insights on SARS-CoV-2 molecular interactions with the renin-angiotensin system

LB Costa, LG Perez, VA Palmeira… - Frontiers in Cell and …, 2020 - frontiersin.org
The emergence of SARS-CoV-2/human/Wuhan/X1/2019, a virus belonging to the species
Severe acute respiratory syndrome-related coronavirus, and the recognition of Coronavirus …

[HTML][HTML] An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

BX Quan, H Shuai, AJ Xia, Y Hou, R Zeng, XL Liu… - Nature …, 2022 - nature.com
Emerging SARS-CoV-2 variants continue to cause waves of new infections globally.
Developing effective antivirals against SARS-CoV-2 and its variants is an urgent task. The …

[HTML][HTML] Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19

H Kai, M Kai - Hypertension Research, 2020 - nature.com
The rapid spread of a novel coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has led to an ongoing pandemic of coronavirus disease 2019 (COVID-19) …

Increasing host cellular receptor—angiotensin‐converting enzyme 2 expression by coronavirus may facilitate 2019‐nCoV (or SARS‐CoV‐2) infection

MW Zhuang, Y Cheng, J Zhang… - Journal of medical …, 2020 - Wiley Online Library
The ongoing outbreak of a new coronavirus (2019‐nCoV, or severe acute respiratory
syndrome coronavirus 2 [SARS‐CoV‐2]) has caused an epidemic of the acute respiratory …

ACE2: its potential role and regulation in severe acute respiratory syndrome and COVID‐19

M Rezaei, SA Ziai, S Fakhri… - Journal of cellular …, 2021 - Wiley Online Library
COVID‐19, a new disease caused by the 2019‐novel coronavirus (SARS‐CoV‐2), has
swept the world and challenged its culture, economy, and health infrastructure. Forced …

[HTML][HTML] Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator

J Bian, Z Li - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) outbreak is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 …

[HTML][HTML] Effects of SARS-CoV-2 on cardiovascular system: the dual role of angiotensin-converting enzyme 2 (ACE2) as the virus receptor and homeostasis regulator …

A Aleksova, G Gagno, G Sinagra, AP Beltrami… - International journal of …, 2021 - mdpi.com
Angiotensin-converting enzyme 2 (ACE2) is the entry receptor for severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), the cause of Coronavirus Disease-2019 (COVID …

[HTML][HTML] ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker

Y Chen, YN Zhang, R Yan, G Wang, Y Zhang… - Signal transduction and …, 2021 - nature.com
The evolution of coronaviruses, such as SARS-CoV-2, makes broad-spectrum coronavirus
preventional or therapeutical strategies highly sought after. Here we report a human …

Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection

X Gao, S Zhang, J Gou, Y Wen, L Fan, J Zhou, G Zhou… - Journal of Infection, 2022 - Elsevier
The ongoing global pandemic of Coronavirus disease 2019 (COVID-19) poses a serious
threat to human health, with patients reportedly suffering from thrombus, vascular injury and …