Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

R Poduri, G Joshi, G Jagadeesh - Cellular signalling, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense,
single-stranded RNA virus that causes the potentially lethal Covid-19 respiratory tract …

[HTML][HTML] Strategies for targeting sars cov-2: Small molecule inhibitors—The current status

NM Beeraka, SP Sadhu… - Frontiers in …, 2020 - frontiersin.org
Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) induced Coronavirus
Disease-19 (COVID-19) cases have been increasing at an alarming rate (7.4 million positive …

[HTML][HTML] Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases

S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …

[PDF][PDF] Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2

V Monteil, H Kwon, P Prado, A Hagelkrüys, RA Wimmer… - Cell, 2020 - cell.com
We have previously provided the first genetic evidence that angiotensin converting enzyme
2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS …

[HTML][HTML] Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV

S Li, Z Tang, Z Li, X Liu - European Journal of Clinical Microbiology & …, 2020 - Springer
Since December 2019, the infection of the new coronavirus (COVID-19) caused an outbreak
of new coronavirus pneumonia in Wuhan, China, and caused great public concern. Both …

[HTML][HTML] Perturbation of the host cell Ca2+ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M

E Poggio, F Vallese, AJW Hartel, TJ Morgenstern… - Cell Death & …, 2023 - nature.com
Abstract Coronavirus disease (COVID-19) is a contagious respiratory disease caused by the
SARS-CoV-2 virus. The clinical phenotypes are variable, ranging from spontaneous …

Potential treatment methods targeting 2019-nCoV infection

LU Zheng, L Zhang, J Huang, KS Nandakumar… - European Journal of …, 2020 - Elsevier
Abstract The novel coronavirus, 2019-nCoV, has quickly spread across the world and pose
serious threat to public health because it can infect people very easily. The major clinical …

Organ‐protective effect of angiotensin‐converting enzyme 2 and its effect on the prognosis of COVID‐19

H Cheng, Y Wang, GQ Wang - Journal of medical virology, 2020 - Wiley Online Library
This article reviews the correlation between angiotensin‐converting enzyme 2 (ACE2) and
severe risk factors for coronavirus disease 2019 (COVID‐19) and the possible mechanisms …

[HTML][HTML] A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants

C Huang, H Shuai, J Qiao, Y Hou, R Zeng… - … and Targeted Therapy, 2023 - nature.com
Abstract Emerging SARS-CoV-2 variants, particularly the Omicron variant and its
sublineages, continually threaten the global public health. Small molecule antivirals are an …

Expression of ACE2 and TMPRSS2 proteins in the upper and lower aerodigestive tracts of rats: implications on COVID 19 infections

T Sato, R Ueha, T Goto, A Yamauchi… - The …, 2021 - Wiley Online Library
Objective Patients with coronavirus disease 2019 (COVID‐19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), exhibit not only respiratory symptoms …