[HTML][HTML] Functional pangenome analysis shows key features of E protein are preserved in SARS and SARS-CoV-2

I Alam, AA Kamau, M Kulmanov, Ł Jaremko… - Frontiers in cellular …, 2020 - frontiersin.org
The spread of the novel coronavirus (SARS-CoV-2) has triggered a global emergency, that
demands urgent solutions for detection and therapy to prevent escalating health, social, and …

[HTML][HTML] Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms

HC Yalcin, V Sukumaran, MKAA Al-Ruweidi… - International Journal of …, 2021 - mdpi.com
The SARS-CoV-2 virus utilizes angiotensin converting enzyme (ACE-2) for cell entry and
infection. This enzyme has important functions in the renin-angiotensin aldosterone system …

[HTML][HTML] A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patient

B Nagy Jr, Z Fejes, Z Szentkereszty, R Sütő… - International Journal of …, 2021 - Elsevier
Endothelial cells express surface angiotensin-converting enzyme 2 (ACE2), the main
receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that promotes …

[HTML][HTML] ACE2 in the era of SARS-CoV-2: controversies and novel perspectives

F Saponaro, G Rutigliano, S Sestito… - Frontiers in Molecular …, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …

Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)

YF Huang, C Bai, F He, Y Xie, H Zhou - Pharmacological research, 2020 - Elsevier
Abstract The Coronavirus Disease 2019 (COVID-19) has been declared as a global
pandemic, but specific medicines and vaccines are still being developed. In China …

Extracellular vesicle‐mediated endothelial apoptosis and EV‐associated proteins correlate with COVID‐19 disease severity

B Krishnamachary, C Cook, A Kumar… - Journal of …, 2021 - Wiley Online Library
Abstract Coronavirus disease‐2019 (COVID‐19), caused by the novel severe acute
respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), has lead to a global pandemic with a …

SARS-CoV-2 bearing a mutation at the S1/S2 cleavage site exhibits attenuated virulence and confers protective immunity

M Sasaki, S Toba, Y Itakura, HM Chambaro… - Mbio, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) possesses a
discriminative polybasic cleavage motif in its spike protein that is recognized by the host …

SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner

YQ Zhou, K Wang, XY Wang, HY Cui… - Emerging Microbes & …, 2022 - Taylor & Francis
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its
variants is threatening public health around the world. Endocytosis functions as an important …

[HTML][HTML] SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

S Li, Y Zhang, Z Guan, H Li, M Ye, X Chen… - Signal transduction and …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to
respiratory illness and multi-organ failure in critically ill patients. Although the virus-induced …

[HTML][HTML] Role of endolysosomes in severe acute respiratory syndrome coronavirus-2 infection and coronavirus disease 2019 pathogenesis: implications for potential …

N Khan, X Chen, JD Geiger - Frontiers in pharmacology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an enveloped, single-
stranded RNA virus. Humans infected with SARS-CoV-2 develop a disease known as …