In 2006, mutations in the granulin gene were identified in patients with familial
Frontotemporal Lobar Degeneration. Granulin transcript haploinsufficiency has been …

Granulin (GRN) mutations have been identified in familial frontotemporal lobar degeneration
patients with ubiquitin pathology. GRN transcript haploinsufficiency is proposed as a …

Granulin (Grn) mutations were identified in familial frontotemporal lobar degeneration
(FTLD) patients with TAR DNA-binding protein of 43 kd (TDP-43) pathology. Grn transcript …

Heterozygous loss-of-function mutations in GRN, the progranulin gene, which result in
progranulin (PGRN) protein haploinsufficiency, are a major cause of frontotemporal lobar …

Mutations in the gene encoding granulin (HUGO gene symbol GRN, also referred to as
progranulin, PGRN), located at chromosome 17q21, were recently linked to tau‐negative …

Background Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal
lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed …

Reduction of Tau protein expression was described in 2003 by Zhukareva et al. in a variant
of frontotemporal lobar degeneration (FTLD) referred to as diagnosis of dementia lacking …

GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions.
The mechanism of pathogenesis is haploinsufficiency. Recently, homozygous GRN …

J. Neurochem.(2010) 112, 1305–1315. Abstract Frontotemporal dementia with ubiquitin‐
positive inclusions (FTLD‐U) can be caused by mutations in the progranulin gene (GRN) …

Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …