The identification of causative mutations in the (pro) granulin gene (GRN) has been a major
breakthrough in the research on frontotemporal dementia (FTD). So far, all FTD-associated …

Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are
overlapping neurodegenerative disorders. Mutations in the growth factor progranulin …

We describe a case of late onset frontotemporal dementia carrying the g. 1977 1980
delCACT (Thr272fs) mutation in progranulin (GRN) gene, characterized by a positive family …

Null mutations in the progranulin gene (PGRN) have been identified as a major cause of
frontotemporal dementia with ubiquitinated inclusions. In this disorder, ubiquitinated …

BACKGROUND: Frontotemporal dementia (FTD) is a neurodegenerative disease
characterized by cognitive impairment, language dysfunction, and/or changes in personality …

Recent studies suggest progranulin (GRN) is a neurotrophic factor. Loss-of-function
mutations in the progranulin gene (GRN) cause frontotemporal lobar degeneration (FTLD), a …

Mutations in progranulin (PGRN) are associated with frontotemporal dementia with or
without parkinsonism. We describe the prominent phenotypic variability within and among …

The clinical phenotype of frontotemporal dementia patients carrying progranulin (GRN)
mutations is known to be heterogeneous. We present a patient with corticobasal syndrome …

Frontotemporal lobar degeneration (FTLD) is a very heterogeneous disorder. It is genetically
linked to three major genes: microtubule-associated protein tau (MAPT), progranulin (GRN) …

Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …