The discovery that mutations in the gene encoding for progranulin (GRN) cause
frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases leading to …

Loss-of-function mutations in the progranulin gene (GRN) are a common cause of familial
frontotemporal lobar degeneration (FTLD). A high degree of heterogeneity in the age-of …

Frontotemporal lobar dementia (FTLD) is the most common cause of dementia in patients
younger than 60 years of age, and causes progressive neurodegeneration of the frontal and …

Mutations within the granulin (GRN) gene that encodes progranulin (PGRN) cause the
neurodegenerative disease frontotemporal lobar degeneration with ubiquitin inclusions …

Frontotemporal lobar degeneration is a fatal neurodegenerative disease that results in
progressive decline in behavior, executive function and sometimes language. Disease …

Mutations within Granulin (GRN) gene are causative of autosomal dominant frontotemporal
lobar degeneration (FTLD). Though GRN mutations are inherited at birth, the disease onset …

The discovery that heterozygous and homozygous mutations in the gene encoding
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …

Frontotemporal lobar degeneration is heterogeneous; cases with tau-and synuclein-
negative, ubiquitin-positive neuronal inclusions are the most common, and some have …

Background Mutation in the progranulin gene (GRN) can cause frontotemporal dementia
(FTD). However, it is unclear whether some rare FTD-relatedGRNvariants are pathogenic …

The most common inherited form of Frontotemporal Lobar Degeneration (FTLD) known
stems from Progranulin (GRN) mutation and exhibits TDP-43 plus ubiquitin aggregates …