[HTML][HTML] Overcoming resistance to natural killer cell based immunotherapies for solid tumors

G Nayyar, Y Chu, MS Cairo - Frontiers in oncology, 2019 - frontiersin.org
Despite advances in the diagnostic and therapeutic modalities, the prognosis of several
solid tumor malignancies remains poor. Different factors associated with solid tumors …

Natural killer cell lines in tumor immunotherapy

M Cheng, J Zhang, W Jiang, Y Chen, Z Tian - Frontiers of medicine, 2012 - Springer
Natural killer (NK) cells are considered to be critical players in anticancer immunity.
However, cancers are able to develop mechanisms to escape NK cell attack or to induce …

[HTML][HTML] Natural killer cell-based therapies targeting cancer: possible strategies to gain and sustain anti-tumor activity

CIM Dahlberg, D Sarhan, M Chrobok, AD Duru… - Frontiers in …, 2015 - frontiersin.org
Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …

[HTML][HTML] NK cell-based cancer immunotherapy: from basic biology to clinical development

S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

[HTML][HTML] Targeting natural killer cells for tumor immunotherapy

C Zhang, Y Hu, C Shi - Frontiers in immunology, 2020 - frontiersin.org
Natural killer (NK) cells are important innate cytotoxic lymphocytes with a rapid and efficient
capacity to recognize and kill tumor cells. In recent years, adoptive transfer of autologous-or …

Natural killer cell-based cancer immunotherapy: a review on 10 years completed clinical trials

WCW Suen, WYW Lee, KT Leung, XH Pan… - Cancer …, 2018 - Taylor & Francis
NK cell cancer immunotherapy is an emerging anti-tumour therapeutic strategy that explores
NK cell stimulation. In this review, we address strategies developed to circumvent limitations …

Targeting natural killer cells in solid tumors

G Habif, A Crinier, P André, E Vivier… - Cellular & molecular …, 2019 - nature.com
Natural killer (NK) cells are innate lymphoid cells endowed with cytolytic activity and a
capacity to secrete cytokines and chemokines. Several lines of evidence suggest that NK …

[HTML][HTML] The application of natural killer cell immunotherapy for the treatment of cancer

K Rezvani, RH Rouce - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are essential components of the innate immune system and play a
critical role in host immunity against cancer. Recent progress in our understanding of NK cell …

[HTML][HTML] Natural killer cells: the linchpin for successful cancer immunotherapy

KA Shaver, TJ Croom-Perez, AJ Copik - Frontiers in immunology, 2021 - frontiersin.org
Cancer immunotherapy is a highly successful and rapidly evolving treatment modality that
works by augmenting the body's own immune system. While various immune stimulation …

[HTML][HTML] Therapeutic potential and challenges of natural killer cells in treatment of solid tumors

A Gras Navarro, AT Björklund, M Chekenya - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …