The Role and Therapeutic Implications of Inflammation in the Pathogenesis of Brain Arteriovenous Malformations

AR Ricciardelli, A Robledo, JE Fish, PT Kan, TH Harris… - Biomedicines, 2023 - mdpi.com
Brain arteriovenous malformations (bAVMs) are focal vascular lesions composed of
abnormal vascular channels without an intervening capillary network. As a result, high …

Neurovascular inflammation in the pathogenesis of brain arteriovenous malformations

S Krithika, S Sumi - Journal of Cellular Physiology, 2021 - Wiley Online Library
Brain arteriovenous malformations (bAVM) arise as congenital or sporadic focal lesions with
a significant risk for intracerebral hemorrhage (ICH). A wide range of interindividual …

[图书][B] Vascular integrity in the pathogenesis of brain arteriovenous malformation

R Zhang, W Zhu, H Su - 2016 - Springer
Brain arteriovenous malformation (bAVM) is an important cause of intracranial hemorrhage
(ICH), particularly in the young population. ICH is the first clinical symptom in about 50% of …

Biology of cerebral arteriovenous malformations with a focus on inflammation

N Mouchtouris, PM Jabbour… - Journal of Cerebral …, 2015 - journals.sagepub.com
Cerebral arteriovenous malformations (AVMs) entail a significant risk of intracerebral
hemorrhage owing to the direct shunting of arterial blood into the venous vasculature …

Current concepts and perspectives on brain arteriovenous malformations: a review of pathogenesis and multidisciplinary treatment

T Sugiyama, G Grasso, F Torregrossa, M Fujimura - World neurosurgery, 2022 - Elsevier
Brain arteriovenous malformations (bAVMs) are unusual vascular pathologies characterized
by the abnormal aggregation of dilated arteries and veins in the brain parenchyma and for …

Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation

R Zhang, Z Han, V Degos, F Shen, EJ Choi, Z Sun… - Angiogenesis, 2016 - Springer
An abnormally high number of macrophages are present in human brain arteriovenous
malformations (bAVM) with or without evidence of prior hemorrhage, causing unresolved …

CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation

L Ma, X Zhu, C Tang, P Pan, A Yadav… - Journal of Cerebral …, 2024 - journals.sagepub.com
Myeloid immune cells are abundant in both ruptured and unruptured brain arteriovenous
malformations (bAVMs). The role of central nervous system (CNS) resident and circulating …

Defective vascular signaling & prospective therapeutic targets in brain arteriovenous malformations

EA Winkler, AY Lu, KP Raygor, JR Linzey… - Neurochemistry …, 2019 - Elsevier
The neurovascular unit is composed of endothelial cells, vascular smooth muscle cells,
pericytes, astrocytes and neurons. Through tightly regulated multi-directional cell signaling …

[HTML][HTML] Cellular loci involved in the development of brain arteriovenous malformations

Z Shabani, J Schuerger, H Su - Frontiers in Human Neuroscience, 2022 - frontiersin.org
Brain arteriovenous malformations (bAVMs) are abnormal vessels that are prone to rupture,
causing life-threatening intracranial bleeding. The mechanism of bAVM formation is not fully …

[HTML][HTML] The role of macrophage in the pathogenesis of brain arteriovenous malformation

L Ma, Y Guo, YL Zhao, H Su - International journal of hematology …, 2015 - ncbi.nlm.nih.gov
Brain arteriovenous malformation (BAVM) is an important risk factor for intracranial
hemorrhage, especially in children and young adults. Inflammation has been implicated in …