Cleft lip and palate (CL/P) is the most prevalent craniofacial birth defect in humans. None of
the surgical procedures currently used for CL/P repair lead to definitive correction of hard …

Background: One of the major difficulties in cleft palate repair is the requirement for several
surgical procedures and autologous bone grafting to form a bony bridge across the cleft …

The use of mucoperiostial flaps during cleft palate surgery is associated with altered palatal
bone growth and development. We analyzed the potential usefulness of a bioengineered …

Regenerative engineering strategies for the oral mucoperiosteum, as may be needed
following surgeries, such as cleft palate repair and tumor resection, are underdeveloped …

Clefts of the lip and/or palate are the most prevalent orofacial birth defects occurring in about
1: 700 live human births worldwide. Early postnatal surgical interventions are extensive and …

Craniofacial bone defect anomalies affect both soft and hard tissues and can be caused by
trauma, bone recessions from tumors and cysts, or even from congenital disorders. On this …

Cleft palate is one of the most common craniofacial defects in newborn babies. The
characteristics of this genetic disease produce soft and hard tissue defects on the lip and …

Cleft palate is a common oral and craniomaxillofacial birth defect. As the ideal surgery time
is shortly after birth, clinical treatments should result in minimal disruption of the skeleton to …

We carried out an in vivo study to evaluate the potential usefulness of a novel bioengineered
bone substitute for the repair of palate defects in laboratory rabbits, using tissue …

An important element of treatment for Cleft lip/cleft palate is the attainment of normal
occlusion. We recultured human bone tissue-derived mesenchymal stromal cells (hBT …