Putative staphylococcal enterotoxin possesses two common structural motifs for MHC-II binding

S Rahman, S Saha, SB Dasgupta, AK Das - International Journal of …, 2024 - Elsevier
Staphylococcus aureus has become a significant cause of health risks in humankind.
Staphylococcal superantigens (SAgs) or enterotoxins are the key virulent factors that can …

Structure of staphylococcal enterotoxin N: Implications for binding properties to its cellular proteins

C Zeng, Z Liu, Z Han - International Journal of Molecular Sciences, 2019 - mdpi.com
Staphylococcus aureus strains produce a unique family of immunostimulatory exotoxins
termed as bacterial superantigens (SAgs), which cross-link major histocompatibility complex …

Superantigen natural affinity maturation revealed by the crystal structure of staphylococcal enterotoxin G and its binding to T‐cell receptor Vβ8. 2

MM Fernández, S Bhattacharya… - PROTEINS …, 2007 - Wiley Online Library
The illnesses associated with bacterial superantigens (SAgs) such as food poisoning and
toxic shock syndrome, as well as the emerging threat of purpura fulminans and community …

Staphylococcal enterotoxin H displays unique MHC class II-binding properties

H Nilsson, P Björk, M Dohlsten… - The Journal of …, 1999 - journals.aai.org
Staphylococcal enterotoxin H (SEH) has been described as a superantigen by sequence
homology with the SEA subfamily and briefly characterized for its in vivo activity. In this …

[HTML][HTML] MHC class II activation and interferon-γ mediate the inhibition of neutrophils and eosinophils by staphylococcal enterotoxin type A (SEA)

AP Ferreira-Duarte, AS Pinheiro-Torres… - Frontiers in cellular …, 2017 - frontiersin.org
Staphylococcal enterotoxins are classified as superantigens that act by linking T-cell
receptor with MHC class II molecules, which are expressed on classical antigen-presenting …

Genome scale analysis of the role of superantigens in Staphylococcus aureus disease pathogenesis

GJC Wilson - 2011 - era.ed.ac.uk
Staphylococcus aureus produces a family of at least 21 distinct superantigens (SAgs) which
include staphylococcal enterotoxins (SEs), staphylococcal enterotoxin-like toxins (SEls), and …

Identification, cloning and characterization of SpEX exotoxin produced by Staphylococcus pseudintermedius

MA Abouelkhair, DA Bemis, RJ Giannone, LA Frank… - Plos one, 2019 - journals.plos.org
Staphylococci have evolved numerous strategies to evade their hosts' immune systems.
Some staphylococcal toxins target essential components of host innate immunity, one of the …

Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules

TL Kissner, G Ruthel, S Alam, RG Ulrich, S Fernandez… - PloS one, 2011 - journals.plos.org
Ligands binding to Toll-like receptor (TLR), interleukin 1 receptor (IL-1R), or IFN-γR1 are
known to trigger MyD88-mediated signaling, which activates pro-inflammatory cytokine …

Structural basis for the neutralization and specificity of Staphylococcal enterotoxin B against its MHC Class II binding site

T Xia, S Liang, H Wang, S Hu, Y Sun, X Yu, J Han, J Li… - MAbs, 2014 - Taylor & Francis
Staphylococcal enterotoxin (SE) B is among the potent toxins produced by Staphylococcus
aureus that cause toxic shock syndrome (TSS), which can result in multi-organ failure and …

Molecular Characteristics and Pathogenicity of Staphylococcus aureus Exotoxins

Z Zhu, Z Hu, S Li, R Fang, HK Ono, DL Hu - International Journal of …, 2023 - mdpi.com
Staphylococcus aureus stands as one of the most pervasive pathogens given its morbidity
and mortality worldwide due to its roles as an infectious agent that causes a wide variety of …