Basis of virulence in enterotoxin-mediated staphylococcal food poisoning

EL Fisher, M Otto, GYC Cheung - Frontiers in microbiology, 2018 - frontiersin.org
The Staphylococcus aureus enterotoxins are a superfamily of secreted virulence factors that
share structural and functional similarities and possess potent superantigenic activity …

Characterization of Human Type C Enterotoxin Produced by Clinical S. epidermidis Isolates

C Nanoukon, D Affolabi, D Keller, R Tollo, P Riegel… - Toxins, 2018 - mdpi.com
Staphylococcal Enterotoxins (SEs) are superantigens (SAg) originally produced by S.
aureus, but their presence in coagulase negative staphylococci (CNS) has long been …

Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells

M Kunkl, C Amormino, F Spallotta, S Caristi… - Frontiers in …, 2023 - frontiersin.org
Staphylococcus aureu s superantigens (SAgs) such as staphylococcal enterotoxin A (SEA)
and B (SEB) are potent toxins stimulating T cells to produce high levels of inflammatory …

Evaluation of a recombinant double mutant of staphylococcal enterotoxin B (SEB-H32Q/K173E) with enhanced antitumor activity effects and decreased pyrexia

L Gu, J Yue, Y Zheng, X Zheng, J Wang, Y Wang, J Li… - Plos one, 2013 - journals.plos.org
Background Immunotherapy has been used to improve patient immune function, inhibit
tumor growth and has become a highly promising method of cancer treatment. Highly …

Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens

JNP Brouillard, S Günther, AK Varma, I Gryski… - Journal of molecular …, 2007 - Elsevier
Superantigens (SAgs) are potent microbial toxins that bind simultaneously to T cell receptors
(TCRs) and class II major histocompatibility complex molecules, resulting in the activation …

Staphylococcal enterotoxin U promotes proinflammatory activity of macrophage via up‐regulation of allograft inflammatory factor 1 expression

Y Zhao, J Tang, C Tang - Journal of Food Safety, 2020 - Wiley Online Library
Staphylococcal enterotoxins (SEs) are a wide array of virulence factors produced by
Staphylococcus aureus with potent super‐antigenic activity and they were reported to be …

Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases

D Oliveira, A Borges, M Simões - Toxins, 2018 - mdpi.com
Staphylococcus aureus is a microorganism resident in the skin and nasal membranes with a
dreadful pathogenic potential to cause a variety of community and hospital-acquired …

The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR molecules

M Håkansson, K Petersson, H Nilsson… - Journal of molecular …, 2000 - Elsevier
The X-ray structure of the superantigen staphylococcal enterotoxin H (SEH) has been
determined at 1.69 Å resolution. In this paper we present two structures of zinc-free SEH …

Biological characterization of the zinc site coordinating histidine residues of staphylococcal enterotoxin C2

X Wang, H Zhang, M Xu, Y Cai, C Liu, Z Su… - …, 2009 - microbiologyresearch.org
The bacterial toxin staphylococcal enterotoxin C2 (SEC2) can cause staphylococcal toxic
shock syndrome and food poisoning. Although the previously determined crystal structure of …

Staphylococcal Enterotoxin H Induced Apoptosis of Bovine Mammary Epithelial Cells in Vitro

Y Liu, W Chen, T Ali, R Alkasir, J Yin, G Liu, B Han - Toxins, 2014 - mdpi.com
Staphylococcal enterotoxins (SEs) are powerful superantigenic toxins produced by
Staphylococcus aureus (S. aureus). They can cause food poisoning and toxic shock …