Background: Oxidative stress contributes to adverse atrial remodeling in diabetes mellitus.
This remodeling can be prevented by the PPAR-γ agonist pioglitazone via its antioxidant …

Introduction The pleiotropic effects of glitazones may favorably affect atrial remodeling. We
sought to investigate the effects of peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) …

Background There is increasing evidence implicating atrial mitochondrial dysfunction in the
pathogenesis of atrial fibrillation. In this study, we explored whether alogliptin, a dipeptidyl …

PPAR‐γ Activator as Upstream Therapy for Atrial Fibrillation in Rat. Introduction: The in vivo
role of peroxisome proliferator‐activated receptor (PPAR)‐γ, an essential transcriptional …

Introduction Recent studies have demonstrated that sodium-glucose co-transporter-2
inhibitors (SGLT2-i) reduce the risk of atrial fibrillation (AF) in patients with diabetes mellitus …

Background: Doxorubicin (DOX), a broad-spectrum chemotherapy drug, has life-threatening
cardiotoxicity. Therefore, searching cardioprotective drugs for DOX-induced cardiotoxicity …

Rationale Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are important
mechanisms of atrial remodeling, predisposing to the development of atrial fibrillation (AF) in …

Mitochondrial oxidative stress and dysfunction play an important role of atrial remodeling
and atrial fibrillation (AF) in diabetes mellitus. Endoplasmic reticulum (ER) stress has been …

Long-term nicotine intake is associated with an increased risk of myocardial damage and
dysfunction. However, it remains unclear whether targeting mitochondrial reactive oxygen …

Nicotine contained in traditional cigarettes, hookahs, and e-cigarettes is an important risk
factor for cardiovascular disease. Our previous study showed that macroautophagic flux …