Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA. 1 variant in juvenile, adult and aged Syrian hamsters

L Yuan, H Zhu, P Chen, M Zhou, J Ma, X Liu… - Cellular & Molecular …, 2022 - nature.com
The new predominant circulating SARS-CoV-2 variant, Omicron, can robustly escape
current vaccines and neutralizing antibodies. Although Omicron has been reported to have …

Reduced pathogenicity of the SARS-CoV-2 omicron variant in hamsters

K McMahan, V Giffin, LH Tostanoski, B Chung… - Med, 2022 - cell.com
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
(B. 1.1. 529) variant has proven to be highly transmissible and has outcompeted the Delta …

A heterologous challenge rescues the attenuated immunogenicity of SARS-CoV-2 omicron BA. 1 variant in Syrian hamster model

J Ma, X Liu, M Zhou, P Chen, R Chen, J Wang… - Journal of …, 2023 - Am Soc Microbiol
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is
becoming a dominant circulator and has several mutations in the spike glycoprotein, which …

SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

F Armando, G Beythien, FK Kaiser, L Allnoch… - Nature …, 2022 - nature.com
Since its discovery in 2019, multiple variants of severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) have been identified. This study investigates virus spread and …

SARS‐CoV‐2 Omicron (B. 1.1. 529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage

W Yu, J Wang, Y Yang, C Tang, C Yang… - Journal of Medical …, 2023 - Wiley Online Library
Since the first SARS‐CoV‐2 outbreak in late 2019, the SARS‐CoV‐2 genome has harbored
multiple mutations, especially spike protein mutations. The currently fast‐spreading Omicron …

Convalescence from prototype SARS-CoV-2 protects Syrian hamsters from disease caused by the Omicron variant

KA Ryan, RJ Watson, KR Bewley, C Burton, O Carnell… - BioRxiv, 2021 - biorxiv.org
The mutation profile of the SARS-CoV-2 Omicron variant poses a concern for naturally
acquired and vaccine-induced immunity. We investigated the ability of prior infection with an …

Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA. 1 (B. 1.1. 529) variant in Syrian golden hamsters

M Rissmann, D Noack, D van Riel… - Emerging Microbes & …, 2022 - Taylor & Francis
ABSTRACT The Omicron BA. 1 (B. 1.1. 529) SARS-CoV-2 variant is characterized by a high
number of mutations in the viral genome, associated with immune escape and increased …

Pathogenicity of SARS-CoV-2 Omicron (R346K) variant in Syrian hamsters and its cross-neutralization with different variants of concern

S Mohandas, PD Yadav, G Sapkal, AM Shete… - …, 2022 - thelancet.com
Summary Background SARS-CoV-2 Omicron variant is rampantly spreading across the
globe. We assessed the pathogenicity and immune response generated by BA. 1.1 sub …

Impact of reinfection with SARS-CoV-2 omicron variants in previously infected hamsters

N Shiwa-Sudo, Y Sakai, N Iwata-Yoshikawa… - Journal of …, 2023 - Am Soc Microbiol
The diversity of SARS-CoV-2 mutations raises the possibility of reinfection of individuals
previously infected with earlier variants, and this risk is further increased by the emergence …

The SARS-CoV-2 Omicron (B. 1.1. 529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

S Yuan, ZW Ye, R Liang, K Tang, AJ Zhang, G Lu… - BioRxiv, 2022 - biorxiv.org
The newly emerging SARS-CoV-2 Omicron (B. 1.1. 529) variant first identified in South
Africa in November 2021 is characterized by an unusual number of amino acid mutations in …