Delayed cerebral ischaemia (DCI) after aneurysmal subarachnoid haemorrhage (aSAH) is a
major cause of mortality and morbidity. The pathophysiology of DCI after aSAH is thought to …

Rapid and effective clearance of cell-free haemoglobin after subarachnoid haemorrhage
(SAH) is important to prevent vasospasm and neurotoxicity and improve long-term outcome …

Haptoglobin is the body's first line of defence against the toxicity of extracellular
haemoglobin released following a subarachnoid haemorrhage (SAH). We investigated the …

Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological
deficits. Much of this is related to the effects of blood in the subarachnoid space which …

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating form of stroke frequently
affecting young to middle-aged adults, with an unmet need to improve outcome. This special …

Vasospasm (VS) and delayed cerebral ischemia (DCI) after subarachnoid hemorrhage
(SAH) are thought to greatly affect prognosis. Haptoglobin (Hp) is a hemoglobin-binding …

Objective After aneurysmal subarachnoid haemorrhage (aSAH), extracellular haemoglobin
(Hb) in the subarachnoid space is bound by haptoglobin, neutralising Hb toxicity and …

Delayed ischemic neurological deficit (DIND) is a major driver of adverse outcomes in
patients with aneurysmal subarachnoid hemorrhage (aSAH), defining an unmet need for …

Although the incidence is declining, subarachnoid hemorrhage (SAH) continues to exact a
substantial toll on society, with an estimated 20,000 aneurysmal SAHs (aSAHs) a year in the …

Background Aneurysmal subarachnoid hemorrhage (aSAH) is often complicated by the
occurrence of delayed ischemic neurologic deficits (DIND), which impairs the clinical …