Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage

H Warming, K Deinhardt, P Garland… - Journal of …, 2023 - Wiley Online Library
During subarachnoid haemorrhage, a blood clot forms in the subarachnoid space releasing
extracellular haemoglobin (Hb), which causes oxidative damage and cell death in …

Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury

K Akeret, RM Buzzi, CA Schaer… - Journal of Cerebral …, 2021 - journals.sagepub.com
Secondary brain injury after aneurysmal subarachnoid hemorrhage (SAH-SBI) contributes to
poor outcomes in patients after rupture of an intracranial aneurysm. The lack of diagnostic …

Disturbances of the hemostatic system in patients with aneurysmal subarachnoid hemorrhage

AI Baranich, IA Savin, TF Tabasaranskiy… - … Imeni NN Burdenko, 2018 - europepmc.org
Subarachnoid hemorrhages due to rupture of cerebral aneurysms are characterized by high
mortality. More than 25% of patients who have survived the first hours after aneurysmal SAH …

The association between hemoglobin concentration and clinical outcomes after aneurysmal subarachnoid hemorrhage: Insights from the LongTEAM registry

F Lin, C Lu, R Li, Y Chen, H Han, Y Zhao… - CNS Neuroscience …, 2024 - Wiley Online Library
Objective The aim of this study is to explore whether preoperative hemoglobin levels could
serve as a prospective biomarker for early brain injury in patients with aneurysmal …

Relationship between hemoglobin concentrations and outcomes across subgroups of patients with aneurysmal subarachnoid hemorrhage

AH Kramer, DA Zygun, TP Bleck, AS Dumont… - Neurocritical care, 2009 - Springer
Objective Anemia predicts poor outcome following aneurysmal subarachnoid hemorrhage
(SAH). We hypothesized that this association would be stronger among patients with more …

Factors associated with the development of anemia after subarachnoid hemorrhage

TR Sampson, R Dhar, MN Diringer - Neurocritical care, 2010 - Springer
Introduction Anemia is common after subarachnoid hemorrhage (SAH) and may exacerbate
the reduction in oxygen delivery that underlies delayed cerebral ischemia. Fall in …

Higher hemoglobin is associated with less cerebral infarction, poor outcome, and death after subarachnoid hemorrhage

AM Naidech, J Drescher, ML Ault, A Shaibani… - …, 2006 - journals.lww.com
OBJECTIVE: Higher-goal hemoglobin (hgb) and more packed red blood cell transfusions
lead to worse outcomes in general critical care patients. There are few data on hgb …

Haptoglobin and the development of cerebral artery vasospasm after subarachnoid hemorrhage

M Borsody, A Burke, W Coplin, R Miller-Lotan, A Levy - Neurology, 2006 - AAN Enterprises
Background: Vasospasm is a prolonged constriction of a cerebral artery that is induced by
hemoglobin after subarachnoid hemorrhage (SAH). The subarachnoid blood clot also …

Heme–hemopexin scavenging is active in the brain and associates with outcome after subarachnoid hemorrhage

P Garland, AJ Durnford, AI Okemefuna, J Dunbar… - Stroke, 2016 - Am Heart Assoc
Background and Purpose—Long-term outcome after subarachnoid hemorrhage (SAH) is
potentially linked to cytotoxic heme. Free heme is bound by hemopexin and rapidly …

Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage

M Oddo, A Milby, I Chen, S Frangos, E MacMurtrie… - Stroke, 2009 - Am Heart Assoc
Background and Purpose—The optimal hemoglobin (Hgb) target after aneurysmal
subarachnoid hemorrhage is not precisely known. We sought to examine the threshold of …