Acute platelet response to aneurysmal subarachnoid hemorrhage depends on severity and distribution of bleeding: an observational cohort study

R Rzepliński, K Kostyra, T Skadorwa, M Sługocki… - Neurosurgical …, 2021 - Springer
Microthrombosis after aneurysmal subarachnoid hemorrhage (aSAH) is considered to
initiate neuroinflammation, vessel remodeling, and blood-brain barrier leakage. We aimed to …

Hematologic counts as predictors of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

IRF Da Silva, JA Gomes, A Wachsman… - Journal of critical …, 2017 - Elsevier
Purpose Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity
and mortality, but currently no single clinical method or ancillary test can reliably predict …

Novel treatments in neuroprotection for aneurysmal subarachnoid hemorrhage

RF James, DR Kramer, ZS Aljuboori, G Parikh… - … treatment options in …, 2016 - Springer
Opinion statement New neuroprotective treatments aimed at preventing or minimizing
“delayed brain injury” are attractive areas of investigation and hold the potential to have …

Pathophysiology of early brain injury and its association with delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a review of current literature

DL Alsbrook, M Di Napoli, K Bhatia, M Desai… - Journal of Clinical …, 2023 - mdpi.com
Background: Delayed cerebral ischemia (DCI) is a common and serious complication of
aneurysmal subarachnoid hemorrhage (aSAH). Though many clinical trials have looked at …

Intracranial heme metabolism and cerebral vasospasm after aneurysmal subarachnoid hemorrhage

H Suzuki, M Muramatsu, T Kojima, W Taki - Stroke, 2003 - Am Heart Assoc
Background and Purpose—The goal of this prospective study was to clarify the potential role
of an inducible heme-metabolizing enzyme, heme oxygenase (HO)-1, and an inducible iron …

Pathophysiology of delayed cerebral ischemia after subarachnoid hemorrhage: a review

WS Dodd, D Laurent, AS Dumont… - Journal of the …, 2021 - Am Heart Assoc
Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …

The role of platelet activation and inflammation in early brain injury following subarachnoid hemorrhage

JA Frontera, JJ Provencio, FA Sehba, TM McIntyre… - Neurocritical care, 2017 - Springer
Background Early brain injury (EBI) following aneurysmal subarachnoid hemorrhage (SAH)
is an important predictor of poor functional outcome, yet the underlying mechanism is not …

Unfractionated heparin: multitargeted therapy for delayed neurological deficits induced by subarachnoid hemorrhage

JM Simard, D Schreibman, EF Aldrich, B Stallmeyer… - Neurocritical care, 2010 - Springer
Aneurysmal subarachnoid hemorrhage (SAH) is associated with numerous “delayed
neurological deficits”(DNDs) that have been attributed to multiple pathophysiological …

Anemia after aneurysmal subarachnoid hemorrhage is associated with poor outcome and death

OGS Ayling, GM Ibrahim, NM Alotaibi, PA Gooderham… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Anemia after aneurysmal subarachnoid hemorrhage is common
and potentially modifiable. Here, we first evaluate the effect of anemia on neurological …

Anemia and red blood cell transfusion in aneurysmal subarachnoid hemorrhage

LA Terrett, L McIntyre, AF Turgeon, SW English - Neurocritical Care, 2023 - Springer
Anemia is very common in aneurysmal subarachnoid hemorrhage (aSAH), with
approximately half of the aSAH patient population developing moderate anemia during their …