Vascular burden and cognition: Mediating roles of neurodegeneration and amyloid PET
It remains unclear to what extent cerebrovascular burden relates to amyloid beta (Aβ)
deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with …
deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with …
[HTML][HTML] Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study
J Bernal, S Schreiber, I Menze, A Ostendorf… - Alzheimer's research & …, 2023 - Springer
Background White matter hyperintensities (WMH) in subjects across the Alzheimer's disease
(AD) spectrum with minimal vascular pathology suggests that amyloid pathology—not just …
(AD) spectrum with minimal vascular pathology suggests that amyloid pathology—not just …
Regional white matter hyperintensity influences grey matter atrophy in mild cognitive impairment
The association between cerebrovascular disease pathology (measured by white matter
hyperintensities, WMH) and brain atrophy in early Alzheimer's disease (AD) remain to be …
hyperintensities, WMH) and brain atrophy in early Alzheimer's disease (AD) remain to be …
Relative impact of amyloid-β, lacunes, and downstream imaging markers on cognitive trajectories
Abstract See Cohen (doi: 10.1093/aww183) for a scientific commentary on this article.
Amyloid-β and cerebral small vessel disease are the two major causes of cognitive …
Amyloid-β and cerebral small vessel disease are the two major causes of cognitive …
Association between white matter hyperintensity and medial temporal atrophy at various stages of Alzheimer's disease
Background and purpose Whilst there is evidence implicating small vessel cerebrovascular
disease in the pathogenesis of Alzheimer's disease (AD), its specific contribution to the …
disease in the pathogenesis of Alzheimer's disease (AD), its specific contribution to the …
[HTML][HTML] Small vessel cerebrovascular disease is associated with cognition in prospective Alzheimer's clinical trial participants
CD Morales, D Cotton-Samuel, PJ Lao… - Alzheimer's Research & …, 2024 - Springer
Background Secondary prevention clinical trials for Alzheimer's disease (AD) target amyloid
accumulation in asymptomatic, amyloid-positive individuals, but it is unclear to what extent …
accumulation in asymptomatic, amyloid-positive individuals, but it is unclear to what extent …
Vascular burden and Alzheimer disease pathologic progression
RY Lo, WJ Jagust, M Weiner, P Aisen, M Weiner… - Neurology, 2012 - AAN Enterprises
Objective: To investigate the vascular contribution to longitudinal changes in Alzheimer
disease (AD) biomarkers. Methods: The Alzheimer's Disease Neuroimaging Initiative is a …
disease (AD) biomarkers. Methods: The Alzheimer's Disease Neuroimaging Initiative is a …
Vascular burden score impacts cognition independent of amyloid PET and MRI measures of Alzheimer's disease and vascular brain injury
Background/Objective: To determine the impact of vascular burden on rates of decline in
episodic memory and executive function. We hypothesize that greater vascular burden will …
episodic memory and executive function. We hypothesize that greater vascular burden will …
In pre-clinical AD small vessel disease is associated with altered hippocampal connectivity and atrophy
ABSTRACT Objective Small Vessel Disease (SVD) is known to be associated with higher
AD risk, but its relationship to amyloidosis in the progression of AD is unclear. In this cross …
AD risk, but its relationship to amyloidosis in the progression of AD is unclear. In this cross …
Association of vascular brain injury, neurodegeneration, amyloid, and cognitive trajectory
JW Han, P Maillard, D Harvey, E Fletcher, O Martinez… - Neurology, 2020 - AAN Enterprises
Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …