Atherosclerosis (AS) is a multifactorial disease. Exploration of DNA methylation in regulating
gene transcription in a cell type-and stage-specific manner will shed light on understanding …

Macrophage-derived lipid-laden foam cells from the subendothelium play a crucial role in
the initiation and progression of atherosclerosis. However, the molecule mechanism that …

Objective—The molecular basis of endothelial cell (EC)–specific gene expression is poorly
understood. Roundabout 4 (Robo4) is expressed exclusively in ECs. We previously reported …

Macrophage-mediated inflammatory responses occur throughout all stages of
atherosclerosis. DNA methylation is one of the critical epigenetic mechanisms and is …

The prognosis of patients with advanced arteriosclerosis is bleak due to the lack of
understanding of arteriosclerosis. Epigenetics-based DNA methylation plays an important …

Background The clinical consequences of atherosclerosis are significant source of morbidity
and mortality throughout the world, while the molecular mechanisms of the pathogenesis of …

Objective—Key augmented processes in atherosclerosis have been identified, whereas less
is known about downregulated pathways. Here, we applied a systems biology approach to …

It is accepted that hypertension is a major, independent risk factor for atherosclerotic
cardiovascular ischemic events, which are mainly attributed to the formation of unstable …

Background Atherosclerotic plaque vulnerability is a key feature of atheroprogression and
precipitating acute cardiovascular events. Although the pivotal role of epigenetic regulation …

Background Atherosclerosis is the main cause of cardiovascular diseases such as ischemic
stroke and coronary heart disease. Gene-specific promoter methylation changes have been …