Liver cirrhosis is a major cause of morbidity worldwide and is characterized by the loss of
hepatocytes with interstitial fibrosis. In this review, we discuss the potential uses of …

Hepatocyte growth factor (HGF) stimulates liver regeneration and has the potential to be a
therapeutic agent for fatal liver diseases, including fulminant hepatic failure and liver …

Liver cirrhosis is characterized by hepatic dysfunction with extensive accumulation of fibrous
tissue in the liver. In response to chronic hepatic injury, hepatic portal myofibroblasts and …

Hepatocyte growth factor, a potent mitogen for mature hepatocytes in vitro, seems to function
as a hepatotrophic factor for liver regeneration. We examined the mitogenic effect of …

Hepatocyte growth factor (HGF), originally purified from the plasma of patients with fulminant
hepatic failure, has been shown to carry out various physiological functions. HGF not only …

Hepatic fibrosis/cirrhosis is a common hepatic disease characterized by the hyper-ac-
cumulation of connective tissue components, and hepatic necrosis. Chronic alcohol inges …

Hepatocyte growth factor (HGF), initially identified and molecularly cloned as a potent
mitogen of primary cultured hepatocytes, has multiple activities in a variety of tissues during …

Liver regeneration depends on the proliferation of mature hepatocytes. In the 1980s, the
method for the cultivation of mature hepatocytes provided an opportunity for the discovery of …

Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine that acts on
various epithelial cells to regulate cell growth, movement and morphogenesis, and tissue …

Hepatocyte growth factor (HGF) is a most potent factor for mature parenchymal hepatocytes
in primary culture and may act as a trigger for liver regeneration. We purified HGF from rat …