ABSTRACT Introduction: Aquaporin-4 (AQP4) is a water transporting protein expressed at
the plasma membrane of astrocytes throughout the central nervous system (CNS). Analysis …

Of the several aquaporin (AQP) water channels expressed in the central nervous system,
AQP4 is an attractive target for drug discovery. AQP4 is expressed in astroglia, most strongly …

Background The presence of water channel proteins, aquaporins (AQPs), in the brain led to
intense research in understanding the underlying roles of each of them under normal …

Aquaporin-4 (AQP4) is expressed in astrocytes throughout the central nervous system,
particularly at the blood–brain and brain–cerebrospinal fluid barriers. Phenotype analysis of …

Stroke is a complex and devastating neurological condition with limited treatment options.
Brain edema is a serious complication of stroke. Early edema formation can significantly …

The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the
principal member of this protein family in the CNS, where it is expressed in astrocytes and is …

Summary Aquaporin 4 (AQP 4) is the main water channel in the central nervous system
(CNS) and specifically localized to astrocyte processes. Recent studies indicate that AQP 4 …

Aquaporin-4 (AQP4) is the major water channel in the CNS. Its expression at fluid-tissue
barriers (blood–brain and brain–cerebrospinal fluid barriers) throughout the brain and spinal …

Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in
all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ …

The regulation of water balance in the brain is crucial. A disruption in this equilibrium causes
an increase in brain water content that significantly contributes to the pathophysiology of …