DNA double-strand breaks (DSBs) are one of the most cytotoxic types of DNA lesion
challenging genome integrity. The activity of cyclin-dependent kinase Cdk1 is essential for …

Cell division and the response to genotoxic stress are intimately connected in eukaryotes,
for example, by checkpoint pathways that signal the presence of DNA damage or its ongoing …

Ubiquitin mediated degradation of cyclin D1 following the G1/S transition counters its
mitogen-dependent accumulation during G1 phase of the cell cycle. Although the cellular …

The human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most
frequently amplified genes in human cancers. Cyclin D1 activates the cyclin-dependent …

The eukaryotic cell cycle comprises a series of events, whose ordering and correct
progression depends on the oscillating activity of cyclin-dependent kinases (Cdks), which …

DNA double-strand breaks (DSBs) contribute to genome instability, a key feature of cancer.
DSBs are mainly repaired by homologous recombination (HR) and non-homologous end …

The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …

Cyclin‐dependent kinase 9 (CDK9) is a well‐characterized subunit of the positive
transcription elongation factor b complex in which it regulates transcription elongation in …

Cyclin-dependent kinases (CDKs) coordinate cell cycle checkpoints with DNA repair
mechanisms that together maintain genome stability. However, the myriad mechanisms that …

Deregulation of cyclin D1 occurs in numerous human cancers through mutations, alternative
splicing, and gene amplification. Although cancer-derived cyclin D1 mutants are potent …