Mechanical ventilation is an uncomfortable and potentially painful intervention. Opioids,
such as morphine and fentanyl, are used for analgesia and sedation but there is uncertainty …

Attention to comfort and pain control are essential components of neonatal intensive care.
Preterm neonates are uniquely susceptible to pain and agitation, and these exposures have …

Infants might be exposed to pain during their admissions in the neonatal intensive care unit
[NICU], both from their underlying conditions and several invasive procedures required …

OBJECTIVE To compare the efficacy and safety of dexmedetomidine and fentanyl for
sedation in mechanically ventilated premature neonates. METHODS This was a …

BACKGROUND:: Endotracheal intubation and mechanical ventilation are major components
of routine intensive care for very low birth weight newborns and sick full-term newborns …

Preterm infants are exposed to frequent painful procedures and agitating stimuli over the
many weeks of their hospitalization in the neonatal intensive care unit (NICU). The adverse …

Opioids and benzodiazepines have historically been employed for pain relief; however, they
are associated with detrimental long-term neurodevelopmental consequences …

Mechanical ventilation is a stressful experience in neonates resulting in changes in
neuroendocrine parameters, pain scores, and physiologic responses. Assisted ventilation in …

Effective sedation and analgesia in the critically ill child ensures physical comfort and
minimises psychological distress. In the UK the most commonly used sedative and …

BACKGROUND Opioids and benzodiazepines have been the mainstay of neonatal
analgesia and sedation. However, based on evidence in neonatal animals, these drugs may …