Two distinct Cl/anion exchange activities (Cl/HCO3and Cl/OH) identified in apical
membranes of rat distal colon are distributed in cell type-specific patterns …

Studies with apical membrane vesicles have shown that two distinct and separate anion
exchange processes are present in rat distal colon, 4, 4′-diisothiocyanatostilbene-2, 2 …

Mutations in human DRA cause congenital chloride diarrhea, thereby raising the possibility
that it functions as a Cl−/HCO 3− exchanger. To test this hypothesis we cloned a cDNA …

BACKGROUND & AIMS:: Duodenal bicarbonate secretion is in part mediated by an apical
Cl−/HCO3− exchanger of unknown molecular nature. The recently discovered dra (down …

In rat ileum and colon, apical membrane exchange and net Cl-absorption are stimulated by
increases in Pco2 or. Because changes in Pco2 stimulate colonic Na+ absorption, in part, by …

Electroneutral NaCl absorption in the intestine is mediated by parallel Na+/H+ and Cl−/HCO
3− exchange. Mutations in the down-regulated in adenoma (DRA) gene cause congenital …

The Na/H exchanger 3 (NHE3) and the Cl/HCO 3 exchanger down-regulated in adenoma
(DRA) together facilitate intestinal electroneutral NaCl absorption. Elevated Ca 2+ i inhibits …

DRA (down regulated in adenoma, SLC26A3) is an anion exchanger that mediates
electroneutral NaCl absorption in the ileum and proximal colon together with NHE3 (Na/H …

In rat distal colon, aldosterone has little effect on Na+ channel (ENaC) α-subunit levels but
increases the expression of the β-and γ-subunits and stimulates electrogenic Na+ transport …

The colon is believed to absorb NaCl via the coupled operation of apical Na/H exchanger-3
(NHE3) and Cl/HCO3 exchanger SLC26A3 (DRA). Efficient coupling requires that NHE3 …