Regulation of DRA and AE1 in rat colon by dietary Na depletion
VM Rajendran, J Black, TA Ardito… - American Journal …, 2000 - journals.physiology.org
Two distinct Cl/anion exchange activities (Cl/HCO3and Cl/OH) identified in apical
membranes of rat distal colon are distributed in cell type-specific patterns …
membranes of rat distal colon are distributed in cell type-specific patterns …
Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells
Studies with apical membrane vesicles have shown that two distinct and separate anion
exchange processes are present in rat distal colon, 4, 4′-diisothiocyanatostilbene-2, 2 …
exchange processes are present in rat distal colon, 4, 4′-diisothiocyanatostilbene-2, 2 …
Mouse down-regulated in adenoma (DRA) is an intestinal Cl−/HCO3− exchanger and is up-regulated in colon of mice lacking the NHE3 Na+/H+ exchanger
JE Melvin, K Park, L Richardson, PJ Schultheis… - Journal of Biological …, 1999 - ASBMB
Mutations in human DRA cause congenital chloride diarrhea, thereby raising the possibility
that it functions as a Cl−/HCO 3− exchanger. To test this hypothesis we cloned a cDNA …
that it functions as a Cl−/HCO 3− exchanger. To test this hypothesis we cloned a cDNA …
Down-regulated in adenoma mediates apical Cl−/HCO3− exchange in rabbit, rat, and human duodenum
P Jacob, H Rossmann, G Lamprecht, A Kretz, C Neff… - Gastroenterology, 2002 - Elsevier
BACKGROUND & AIMS:: Duodenal bicarbonate secretion is in part mediated by an apical
Cl−/HCO3− exchanger of unknown molecular nature. The recently discovered dra (down …
Cl−/HCO3− exchanger of unknown molecular nature. The recently discovered dra (down …
Acid-base effects on intestinal Cl- absorption and vesicular trafficking
AN Charney, RW Egnor, D Henner… - … of Physiology-Cell …, 2004 - journals.physiology.org
In rat ileum and colon, apical membrane exchange and net Cl-absorption are stimulated by
increases in Pco2 or. Because changes in Pco2 stimulate colonic Na+ absorption, in part, by …
increases in Pco2 or. Because changes in Pco2 stimulate colonic Na+ absorption, in part, by …
Transport properties of the human intestinal anion exchanger DRA (down-regulated in adenoma) in transfected HEK293 cells
G Lamprecht, S Baisch, E Schoenleber, M Gregor - Pflügers Archiv, 2005 - Springer
Electroneutral NaCl absorption in the intestine is mediated by parallel Na+/H+ and Cl−/HCO
3− exchange. Mutations in the down-regulated in adenoma (DRA) gene cause congenital …
3− exchange. Mutations in the down-regulated in adenoma (DRA) gene cause congenital …
Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium
G Lamprecht, CJ Hsieh, S Lissner, L Nold, A Heil… - Journal of Biological …, 2009 - ASBMB
The Na/H exchanger 3 (NHE3) and the Cl/HCO 3 exchanger down-regulated in adenoma
(DRA) together facilitate intestinal electroneutral NaCl absorption. Elevated Ca 2+ i inhibits …
(DRA) together facilitate intestinal electroneutral NaCl absorption. Elevated Ca 2+ i inhibits …
Chloride and bicarbonate have similar affinities to the intestinal anion exchanger DRA (down regulated in adenoma)
G Lamprecht, J Schaefer, K Dietz, M Gregor - Pfluegers Archiv, 2006 - Springer
DRA (down regulated in adenoma, SLC26A3) is an anion exchanger that mediates
electroneutral NaCl absorption in the ileum and proximal colon together with NHE3 (Na/H …
electroneutral NaCl absorption in the ileum and proximal colon together with NHE3 (Na/H …
Segmental variability of ENaC subunit expression in rat colon during dietary sodium depletion
E Greig, E Baker, T Mathialahan, R Boot-Handford… - Pflügers Archiv, 2002 - Springer
In rat distal colon, aldosterone has little effect on Na+ channel (ENaC) α-subunit levels but
increases the expression of the β-and γ-subunits and stimulates electrogenic Na+ transport …
increases the expression of the β-and γ-subunits and stimulates electrogenic Na+ transport …
Segregation of Na/H exchanger-3 and Cl/HCO3 exchanger SLC26A3 (DRA) in rodent cecum and colon
C Talbot, C Lytle - American Journal of Physiology …, 2010 - journals.physiology.org
The colon is believed to absorb NaCl via the coupled operation of apical Na/H exchanger-3
(NHE3) and Cl/HCO3 exchanger SLC26A3 (DRA). Efficient coupling requires that NHE3 …
(NHE3) and Cl/HCO3 exchanger SLC26A3 (DRA). Efficient coupling requires that NHE3 …