Purinergic signalling is involved in the control of vascular tone and remodelling. Endothelial
cells release purines and pyrimidines in response to changes in blood flow (evoking shear …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

There are nineteen different receptor proteins for adenosine, adenine and uridine
nucleotides, and nucleotide sugars, belonging to three families of G protein-coupled …

Summary 1 Purinergic signalling is involved both in short‐term control of vascular tone and
in longer‐term control of cell proliferation, migration and death involved in vascular …

Atherosclerosis is the main pathological basis of cardiovascular disease and involves
damage to vascular endothelial cells (ECs) that results in endothelial dysfunction (ED). The …

Evidence for the role of purinergic signaling (via P1 and P2Y receptors) in the proliferation of
vascular smooth muscle and endothelial cells is reviewed. The involvement of the mitogen …

There is nervous control of the heart by ATP as a cotransmitter in sympathetic,
parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in …

In this Commentary, the roles of uridine adenosine tetraphosphate as an endothelium‐
derived contracting or relaxing factor described in the paper by Tölle et al. are considered …

Purinergic G-protein-coupled receptors are ancient and the most abundant group of G-
protein-coupled receptors (GPCRs). The wide distribution of purinergic receptors in the …

Increased vascular permeability is a hallmark of several cardiovascular anomalies, including
ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and …