Polycomb group (PcG) proteins and Pax6 cooperate to inhibit in vivo reprogramming of the developing Drosophila eye

J Zhu, AJ Ordway, L Weber, K Buddika… - …, 2018 - journals.biologists.com
How different cells and tissues commit to and determine their fates has been a central
question in developmental biology since the seminal embryological experiments conducted …

Pax6 induces ectopic eyes in a vertebrate

RL Chow, CR Altmann, RA Lang… - …, 1999 - journals.biologists.com
We report here that misexpression of the transcription factor Pax6 in the vertebrate Xenopus
laevis leads to the formation of differentiated ectopic eyes. Multiple molecular markers …

Drosophila Pax6 promotes development of the entire eye-antennal disc, thereby ensuring proper adult head formation

J Zhu, S Palliyil, C Ran… - Proceedings of the …, 2017 - National Acad Sciences
Paired box 6 (Pax6) is considered to be the master control gene for eye development in all
seeing animals studied so far. In vertebrates, it is required not only for lens/retina formation …

Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium

LR Baker, BM Weasner, A Nagel, SD Neuman… - …, 2018 - journals.biologists.com
The transcription factor Pax6 is considered the master control gene for eye formation
because (1) it is present within the genomes and retina/lens of all animals with a visual …

Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies

Y Onuma, S Takahashi, M Asashima… - Proceedings of the …, 2002 - National Acad Sciences
Loss of Pax 6 function leads to an eyeless phenotype in both mammals and insects, and
ectopic expression of both the Drosophila and the mouse gene leads to the induction of …

Revisiting a classic example of transcription factor functional equivalence: are Eyeless and Pax6 functionally equivalent or divergent?

VJ Lynch, GP Wagner - Journal of Experimental Zoology Part B …, 2011 - Wiley Online Library
A major, and sometimes heated, debate in evolutionary and developmental biology is about
the genetic basis of morphological evolution and the molecular mechanisms of gene …

Eye specification in Drosophila: perspectives and implications

JP Kumar, K Moses - Seminars in Cell & Developmental Biology, 2001 - Elsevier
The discovery that Drosophilaeyeless is homologous to vertebrate Pax6 produced
enormous interest in eye specification and a reappraisal of eye evolution. While the …

A multi-gene knockdown approach reveals a new role for Pax6 in controlling organ number in Drosophila

AJ Ordway, GM Teeters, BM Weasner… - …, 2021 - journals.biologists.com
Genetic screens are designed to target individual genes for the practical reason of
establishing a clear association between a mutant phenotype and a single genetic locus …

[HTML][HTML] Differential requirements for the Pax6 (5a) genes eyegone and twin of eyegone during eye development in Drosophila

JG Yao, BM Weasner, LH Wang, CC Jang… - Developmental …, 2008 - Elsevier
In eye development the tasks of tissue specification and cell proliferation are regulated, in
part, by the Pax6 and Pax6 (5a) proteins respectively. In vertebrates, Pax6 (5a) is generated …

Pax6: more than meets the eye

I Hanson, V Van Heyningen - Trends in Genetics, 1995 - cell.com
The paired-box motif, originally defined in Drosophila segmentation genes, is conserved in
the Pax family of vertebrate developmental genes. Mutations that reduce Pax6 dosage …