STR-324 is the chemically stable analog of opiorphin, a human pentapeptide (Gln-Arg-Phe-
Ser-Arg), that inhibits two enkephalinases, aminopeptidase-N and neutral endopeptidase …

Background Opiorphin is a naturally occurring potent analgesic human peptide. It protects
enkephalins from degradation and inhibits pain perception in various acute pain models via …

ACUTE pain after noncardiac surgery provokes suffering, activates the sympathetic nervous
system which augments myocardial demand, delays mobilization and recovery, and may …

Background Stress-induced analgesia is a well recognized phenomenon in animals and
humans in which endogenous opioids have been implicated. However, analgesia induced …

BACKGROUND: Neuropathic pain represents a therapeutic challenge, and treatments with
increased efficacy and tolerability still need to be developed. Opiorphin protects …

In a randomised controlled clinical trial published in this issue of the European Journal of
Anaesthesiology, Song et al. 1 analyse the effect of dexmedetomidine as part of an opioid …

Aim Dual enkephalinase inhibitors (DENKIs) are involved in the regulation of nociception via
opioid receptors. The novel compound STR‐324 belongs to the DENKI pharmacological …

University of Nebraska Medical Center, USA Inadequate perioperative pain control delays
postoperative mobilization, and may lead to development of chronic postoperative pain …

Editorial Views reported by liu et al. involves protease-activated receptor-4 because
previous work indicated that activation of this receptor mediates inflammation and acts in an …

Current clinical practices designed to minimize pain in the perioperative period should be
based on scientific evidence from the peer-reviewed medical literature. 1 The recent and …