The biological activities of oleocanthal from a molecular perspective

KL Pang, KY Chin - Nutrients, 2018 - mdpi.com
Oleocanthal is a minor constituent of olive oil with strong anti-inflammatory activities. Since
the pathogenesis of many chronic diseases involves inflammatory and oxidative …

Current disease-targets for oleocanthal as promising natural therapeutic agent

A Segura-Carretero, JA Curiel - International Journal of Molecular …, 2018 - mdpi.com
The broad number of health benefits which can be obtained from the long-term consumption
of olive oil are attributed mainly to its phenolic fraction. Many olive oil phenolics have been …

Oleocanthal, a phenolic derived from virgin olive oil: A review of the beneficial effects on inflammatory disease

L Parkinson, R Keast - International journal of molecular sciences, 2014 - mdpi.com
Virgin olive oil (VOO) is credited as being one of many healthful components of the
Mediterranean diet. Mediterranean populations experience reduced incidence of chronic …

New drugs from ancient natural foods. Oleocanthal, the natural occurring spicy compound of olive oil: a brief history

M Scotece, J Conde, V Abella, V Lopez, J Pino… - Drug Discovery …, 2015 - Elsevier
Highlights•Oleocanthal is an active constituent of extra virgin olive oil that contributes to the
well-known healthy effect of the Mediterranean diet.•In vitro studies suggest a therapeutic …

Oleocanthal ameliorates amyloid-β oligomers' toxicity on astrocytes and neuronal cells: In vitro studies

YS Batarseh, LA Mohamed, SB Al Rihani, YM Mousa… - Neuroscience, 2017 - Elsevier
Extra-virgin olive oil (EVOO) has several health promoting effects. Evidence have shown that
EVOO attenuates the pathology of amyloid-β (Aβ) and improves cognitive function in …

Cytotoxic activity of oleocanthal isolated from virgin olive oil on human melanoma cells

S Fogli, C Arena, S Carpi, B Polini, S Bertini… - Nutrition and …, 2016 - Taylor & Francis
Oleocanthal is one of the phenolic compounds of extra virgin olive oil with important anti-
inflammatory properties. Although its potential anticancer activity has been reported, only …

Anticancer molecular mechanisms of oleocanthal

M El Haouari, JE Quintero… - Phytotherapy Research, 2020 - Wiley Online Library
Cancer is among the leading causes of mortality worldwide. Current cancer therapies are
associated with serious side effects, which further damage patients' health. Therefore, the …

Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells

S Cirmi, M Celano, GE Lombardo, V Maggisano… - Food & function, 2020 - pubs.rsc.org
Several studies published in the last decade suggest that the beneficial role of extra-virgin
olive oil (EVOO) in human health is mostly attributable to the main secoiridoid derivatives …

Oleanolic acid alters multiple cell signaling pathways: implication in cancer prevention and therapy

L Žiberna, D Šamec, A Mocan, SF Nabavi… - International journal of …, 2017 - mdpi.com
Nowadays, much attention has been paid to diet and dietary supplements as a cost-effective
therapeutic strategy for prevention and treatment of a myriad of chronic and degenerative …

Comparison survey of EVOO polyphenols and exploration of healthy aging-promoting properties of oleocanthal and oleacein

T Nikou, V Liaki, P Stathopoulos, AD Sklirou… - Food and Chemical …, 2019 - Elsevier
Olive oil is widely accepted as a superior edible oil. Great attention has been given lately to
olive oil polyphenols which are linked to significant health beneficial effects. Towards a …