[HTML][HTML] Oleanolic acid and its derivatives: biological activities and therapeutic potential in chronic diseases

TB Ayeleso, MG Matumba, E Mukwevho - Molecules, 2017 - mdpi.com
The increasing demand for natural products as an alternative therapy for chronic diseases
has encouraged research into the pharmacological importance of bioactive compounds from …

[HTML][HTML] Analysis of Antioxidant and Antiviral Effects of Olive (Olea europaea L.) Leaf Extracts and Pure Compound Using Cancer Cell Model

R Pennisi, I Ben Amor, B Gargouri, H Attia, R Zaabi… - Biomolecules, 2023 - mdpi.com
The present study aims to assess the antioxidant and antiviral effectiveness of leaf extracts
obtained from Olea europaea L. var. sativa and Olea europaea L. var. sylvestris. The total …

[HTML][HTML] Insights into the Antioxidant/Antiradical Effects and In Vitro Intestinal Permeation of Oleocanthal and Its Metabolites Tyrosol and Oleocanthalic Acid

D Cuffaro, D Pinto, AM Silva, A Bertolini, S Bertini… - Molecules, 2023 - mdpi.com
(1) Background: In recent years, numerous studies have highlighted the beneficial effects of
extra virgin olive oil (EVOO) as an active ingredient against chronic diseases. The properties …

[HTML][HTML] Extra-Virgin Olive Oil in Alzheimer's Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies

AE Alkhalifa, NF Al-Ghraiybah, A Kaddoumi - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by several pathological hallmarks, including the deposition of amyloid-β (Aβ) plaques …

[HTML][HTML] miRNA modulation and antitumor activity by the extra-virgin olive oil polyphenol oleacein in human melanoma cells

S Carpi, B Polini, C Manera, M Digiacomo… - Frontiers in …, 2020 - frontiersin.org
Extra-virgin olive oil (EVOO) polyphenols contribute to Mediterranean diet health-promoting
properties. One of the most abundant secoiridoid present in EVOO, Oleacein (OA) …

[HTML][HTML] Anti-tumor activity and epigenetic impact of the polyphenol oleacein in multiple myeloma

G Juli, M Oliverio, D Bellizzi, ME Gallo Cantafio… - Cancers, 2019 - mdpi.com
Olive oil contains different biologically active polyphenols, among which oleacein, the most
abundant secoiridoid, has recently emerged for its beneficial properties in various disease …

[HTML][HTML] Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action

ZY Tang, Y Li, YT Tang, XD Ma, ZY Tang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Oleanolic acid (OA, 3 β-hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic
triterpenoid present in many plants. As a new framework for development of semi synthetic …

Anticancer effects of oleuropein

H Shamshoum, F Vlavcheski, E Tsiani - Biofactors, 2017 - Wiley Online Library
Cancer cells exhibit enhanced proliferation rate and a resistance to apoptosis.
Epidemiological studies suggest that olive oil intake is associated with a reduced risk of …

Olea europaea L-derived secoiridoids: Beneficial health effects and potential therapeutic approaches

S Filardo, M Roberto, D Di Risola, L Mosca… - Pharmacology & …, 2024 - Elsevier
Over the years, health challenges have become increasingly complex and global and, at the
beginning of the 21st century, chronic diseases, including cardiovascular, neurological, and …

An overview of the modulatory effects of oleic acid in health and disease

H Sales-Campos, P Reis de Souza… - Mini reviews in …, 2013 - ingentaconnect.com
Evidences in the last years have showed the effects of oleic acid (OA) in human health and
disease. Olive oil, rich in oleic acid, is supposed to present modulatory effects in a wide …