The complement system is an essential effector of innate immunity that plays a crucial role in
the defense against common pathogens and in host homeostasis. 1 Therefore, patients with …

Complement (C) 3 glomerulop-athy (C3G) is a rare, complement-mediated disorder that
encompasses C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Drivers …

C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS) are two rare
diseases caused by dysregulated activity of the alternative pathway of complement …

Recently, a number of reports have described dominant C3 deposits in renal biopsies of
patients with infection-related glomerulonephritis (GN). While acute post-infectious GN and …

The complement system is an essential part of innate immunity acting as a first-line defense
against infection and provides an interface between innate and adaptive immunity (1, 2). It …

Complement factor 3 glomerulopathy (C3G) is caused by dysregulation of the alternative
complement pathway (AP), resulting in either dense deposit disease or complement factor 3 …

The impairment of the alternative complement pathway contributes to rare kidney diseases
such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). We …

Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising of
dense deposit disease and C3 glomerulonephritis. The key histological feature is the …

In 2010, we suggested the name C3 glomerulopathy to encompass a group of glomerular
diseases characterized by the presence of glomerular C3 in the absence of substantial Ig …

C3 glomerulopathy is a rare and complex renal disease driven by complement
dysregulation, with variable presentation and pathophysiology. We report the case of a …