A growing body of work points toward the existence of a clinically symptomatic prodromal
phase in multiple sclerosis (MS) that might span 5–10 years or more. A prodrome is an early …

A prodrome is an early set of signs, symptoms or other findings that occur before the onset of
typical symptoms of a disease. Prodromal phases are well recognized in several …

A prodrome is considered an early set of signs or symptoms indicating the onset of a
disease or illness. In multiple sclerosis (MS), the prodromal period is the months or years …

A prodrome is an early set of signs or symptoms that indicate the onset of a disease before
more typical symptoms develop. Prodromal stages are well recognized in some neurological …

Introduction The identification of a prodromal phase in multiple sclerosis (MS) could have
major implications for earlier recognition and management of MS. The authors conducted a …

A prodrome is an early set of symptoms, which indicates the onset of a disease; these
symptoms are often non-specific. Prodromal phases are now recognized in multiple central …

Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of
MS is not yet known, although epidemiological data indicate that both genetic and …

Following the extraordinary progress in the treatment of multiple sclerosis (MS), two major
unmet needs remain: understanding the etiology of the disease and, hence, designing …

The conversion of relapsing-remitting multiple sclerosis (RRMS) to secondary progressive
MS (SPMS) cannot be defined by a sharp threshold determined by event-based measures …

Background: There is growing evidence of a prodromal period in multiple sclerosis (MS). A
better understanding of the prodrome may facilitate prompt recognition and treatment of MS …