Mouse oocytes at different stages of maturation were fused together and the ensuing cell
cycle events were analyzed with the objective of identifying checkpoints in meiosis. Fusion …

Mammalian oocytes are arrested in meiotic prophase for prolonged periods, and then
resume meiosis in response to luteinizing hormone from the pituitary, which binds to the …

Meiosis is a special type of cell division designed to produce haploid germ cells (see Box 1).
From the standpoint of cell cycle regulation, meiosis in animal oocytes is intriguing since …

Fully grown mouse oocytes are normally competent to progress from prophase I to
metaphase II without interruption. However, growing mouse oocytes initially become only …

Some mammalian oocytes fail to complete maturation in vitro and arrest development at the
first metaphase stage. The response of such blocked oocytes to sperm penetration was …

Abstract “Meiotic maturation” of mouse oocytes takes place during the final phase of
oogenesis and refers specifically to the process of nuclear progression from the diplotene …

During mitosis, a spindle checkpoint detects chromosome misalignment and halts the cell
cycle progression. In meiosis of female germ cells, however, it is debatable whether such a …

During the haploidization process, it is expected that diploid chromosomes of somatic cells
will be reduced to haploid for the generation of artificial gametes. In the present study, we …

Fully grown, but not growing, mammalian oocytes spontaneously resume meiosis in vitro.
Resumption of meiosis, also known as oocyte maturation, is associated with a drop in …

We analyzed progression through the meiotic maturation in oocytes manipulated to replace
the prophase oocyte nucleus with the nucleus from a cumulus cell, a pachytene …