Assessing exposure to tobacco-specific carcinogen NNK using its urinary metabolite NNAL measured in US population: 2011–2012

B Wei, BC Blount, B Xia, L Wang - Journal of exposure science & …, 2016 - nature.com
Carcinogenic tobacco-specific nitrosamines (TSNAs) such as 4-(methylnitrosamino)-1-(3-
pyridyl)-1-butanone (NNK) are found only in tobacco and derived products. Food and Drug …

Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in smokers in the United States: NHANES 2007–2008

Y Xia, JT Bernert, RB Jain, DL Ashley, JL Pirkle - Biomarkers, 2011 - Taylor & Francis
The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a
metabolite of the tobacco-specific nitrosamine (TSNA) 4-(methylnitrosamino)-1-(3-pyridyl)-1 …

Urine concentrations of a tobacco-specific nitrosamine carcinogen in the US population from secondhand smoke exposure

JT Bernert, JL Pirkle, Y Xia, RB Jain, DL Ashley… - … , biomarkers & prevention, 2010 - AACR
Background: The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) and its reduction product in the body, 4-(methylnitrosamino)-1-(3-pyridyl)-1 …

Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users

SS Hecht, SG Carmella, I Stepanov, J Jensen… - … Biomarkers & Prevention, 2008 - AACR
Abstract The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is one of the most abundant carcinogens in smokeless tobacco products. NNK uptake …

Direct analysis of tobacco-specific nitrosamine NNK and its metabolite NNAL in human urine by LC–MS/MS: evidence of linkage to methylated DNA lesions

CW Hu, YW Hsu, JL Chen, LM Tam, MR Chao - Archives of toxicology, 2014 - Springer
(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its urinary metabolite, 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), are the most investigated carcinogenic …

Tobacco-specific nitrosamines (NNAL, NNN, NAT, and NAB) exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014)

B Xia, BC Blount, T Guillot, C Brosius… - Nicotine and …, 2021 - academic.oup.com
Introduction The tobacco-specific nitrosamines (TSNAs) are an important group of
carcinogens found in tobacco and tobacco smoke. To describe and characterize the levels …

Exposure and metabolic activation biomarkers of carcinogenic tobacco-specific nitrosamines

SS Hecht, I Stepanov, SG Carmella - Accounts of chemical …, 2016 - ACS Publications
Conspectus Lung cancer is the leading cause of cancer death in the world, and cigarette
smoking is its main cause. Oral cavity cancer is another debilitating and often fatal cancer …

Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid …

P Jacob III, C Havel, DH Lee, L Yu, MD Eisner… - Analytical …, 2008 - ACS Publications
Exposure to secondhand tobacco smoke (SHS) has been linked to increased risk for a
number of diseases, including lung cancer. The tobacco-specific nitrosamine 4 …

TSNA exposure: levels of NNAL among Canadian tobacco users

CD Czoli, D Hammond - Nicotine & Tobacco Research, 2015 - academic.oup.com
Introduction: Tobacco smoke contains more than 7,000 chemicals, including known
carcinogens, such as tobacco-specific nitrosamines (TSNAs). TSNA levels in cigarettes vary …

Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers

DL Ashley, RJ O'Connor, JT Bernert, CH Watson… - … , biomarkers & prevention, 2010 - AACR
Background: Smokers are exposed to significant doses of carcinogens, including tobacco-
specific nitrosamines (TSNA). Previous studies have shown significant global differences in …