Exosomes derived from hucMSC attenuate renal fibrosis through CK1δ/β-TRCP-mediated YAP degradation

C Ji, J Zhang, Y Zhu, H Shi, S Yin, F Sun, Q Wang… - Cell Death & …, 2020 - nature.com
Exosomes from human umbilical cord mesenchymal stem cells (hucMSC-Ex) have been
suggested as novel nanomaterials for regenerative medicine. Here we explored the roles of …

Stem cell-derived extracellular vesicles inhibit and revert fibrosis progression in a mouse model of diabetic nephropathy

C Grange, S Tritta, M Tapparo, M Cedrino, C Tetta… - Scientific reports, 2019 - nature.com
Extracellular vesicles (EVs) that are derived from mesenchymal stromal cells (MSCs) have
been shown to reprogram injured cells by activating regenerative processes. We herein …

[HTML][HTML] Human mesenchymal stromal cell-derived extracellular vesicles alleviate renal ischemic reperfusion injury and enhance angiogenesis in rats

X Zou, D Gu, X Xing, Z Cheng, D Gong… - American journal of …, 2016 - ncbi.nlm.nih.gov
Background: Mesenchymal stromal cells (MSCs) derived extracellular vesicles (EVs) were
regarded as a potent medium for kidney injury repair and angiogenesis were regarded as …

TGF-β1–containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis

FT Borges, SA Melo, BC Özdemir, N Kato… - Journal of the …, 2013 - journals.lww.com
Hypoxia is associated with tissue injury and fibrosis but its functional role in fibroblast
activation and tissue repair/regeneration is unknown. Using kidney injury as a model …

Mesenchymal stem cell-derived microparticles ameliorate peritubular capillary rarefaction via inhibition of endothelial-mesenchymal transition and decrease …

HY Choi, HG Lee, BS Kim, SH Ahn, A Jung… - Stem cell research & …, 2015 - Springer
Abstract Introduction Microparticles (MPs) derived from kidney-derived mesenchymal stem
cells (KMSCs) have recently been reported to ameliorate rarefaction of peritubular …

Mesenchymal Stem/Stromal Cell–Derived Extracellular Vesicles for Chronic Kidney Disease: Are We There Yet?

A Eirin, LO Lerman - Hypertension, 2021 - Am Heart Assoc
Mesenchymal stem/stromal cells (MSCs) are the most utilized cell type for cellular therapy,
partly due to their important proliferative potential and ability to differentiate into various cell …

In Vivo Tracking of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving Mitochondrial Function in Renal Ischemia–Reperfusion Injury

H Cao, Y Cheng, H Gao, J Zhuang, W Zhang, Q Bian… - ACS …, 2020 - ACS Publications
Extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have exhibited
regenerative capability in animal models of ischemia–reperfusion (I/R) acute kidney injury …

Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats

T Katsuno, T Ozaki, Y Saka, K Furuhashi… - Cell …, 2013 - journals.sagepub.com
Current studies suggest that mesenchymal stromal cells (MSCs) improve acute kidney injury
(AKI) via paracrine/endocrine effects. We established human adipose tissue-derived stromal …

Exosomes from human‐bone‐marrow‐derived mesenchymal stem cells protect against renal ischemia/reperfusion injury via transferring miR‐199a‐3p

G Zhu, L Pei, F Lin, H Yin, X Li, W He… - Journal of cellular …, 2019 - Wiley Online Library
Renal ischemia/reperfusion (I/R) injury is the main reason for acute kidney injury (AKI) and is
closely related to high morbidity and mortality. In this study, we found that exosomes from …

Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer

W Du, K Zhang, S Zhang, R Wang, Y Nie, H Tao, Z Han… - Biomaterials, 2017 - Elsevier
Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates
for the treatment of degenerative diseases or injury and may provide an alternative to cell …