[HTML][HTML] Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy

Y Duan, Q Luo, Y Wang, Y Ma, F Chen, X Zhu… - Journal of biological …, 2020 - ASBMB
Diabetic nephropathy (DN) is a complication of diabetes that is increasing in prevalence in
China. Extracellular vesicles (EVs) carrying microRNAs (miRs) may represent a useful tool …

[HTML][HTML] Mesenchymal stem cell-derived exosomes ameliorated diabetic nephropathy by autophagy induction through the mTOR signaling pathway

N Ebrahim, IA Ahmed, NI Hussien, AA Dessouky… - Cells, 2018 - mdpi.com
Background: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and a
common cause of end-stage renal disease. Autophagy has a defensive role against kidney …

[HTML][HTML] Human adipose mesenchymal stem cell-derived exosomes protect mice from DSS-induced inflammatory bowel disease by promoting intestinal-stem-cell and …

H Yu, X Yang, X Xiao, M Xu, Y Yang, C Xue, X Li… - Aging and …, 2021 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) remains a severe disease for most patients, with its
incidence and prevalence increasingly globally. Currently, there is no effective treatments for …

[HTML][HTML] Exosome and microvesicle-enriched fractions isolated from mesenchymal stem cells by gradient separation showed different molecular signatures and …

F Collino, M Pomatto, S Bruno, RS Lindoso… - Stem cell reviews and …, 2017 - Springer
Several studies have suggested that extracellular vesicles (EVs) released from
mesenchymal stem cells (MSCs) may mediate MSC paracrine action on kidney …

Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension

R Feng, M Ullah, K Chen, Q Ali, Y Lin… - Journal of extracellular …, 2020 - Taylor & Francis
The prevalence of arterial stiffness and hypertension increases with age. This study
investigates the effect of induced pluripotent mesenchymal stem cell-derived extracellular …

[HTML][HTML] The microRNA regulatory landscape of MSC-derived exosomes: a systems view

SW Ferguson, J Wang, CJ Lee, M Liu… - Scientific reports, 2018 - nature.com
Mesenchymal stem cell (MSC)-derived exosomes mediate tissue regeneration in a variety of
diseases including ischemic heart injury, liver fibrosis, and cerebrovascular disease. Despite …

Repeated systemic administration of human adipose-derived stem cells attenuates overt diabetic nephropathy in rats

L Zhang, K Li, X Liu, D Li, C Luo, B Fu… - Stem Cells and …, 2013 - liebertpub.com
Adipose-derived stem cells (ASCs) can alleviate acute kidney injury and promote kidney cell
regeneration and repair. To investigate the role of ASCs in diabetic nephropathy (DN) …

Exosomes from high glucose–treated macrophages activate glomerular mesangial cells via TGF‐β1/Smad3 pathway in vivo and in vitro

QJ Zhu, M Zhu, XX Xu, XM Meng, YG Wu - The FASEB Journal, 2019 - Wiley Online Library
Diabetes nephropathy (DN) is characterized by abnormal interactions between kidney‐
infiltrating macrophages and glomerular mesangial cells. Recently, a novel cell‐cell …

[HTML][HTML] Human umbilical cord mesenchymal stromal cell-derived exosomes protect against MCD-induced NASH in a mouse model

Y Shi, X Yang, S Wang, Y Wu, L Zheng, Y Tang… - Stem cell research & …, 2022 - Springer
Background and aims Human umbilical cord mesenchymal stem cells (hUC-MSCs) are
increasingly being studied in clinical trials of end-stage liver disease because of their good …

Adipose-derived mesenchymal stem cell exosomes: a novel pathway for tissues repair

Y Fang, Y Zhang, J Zhou, K Cao - Cell and Tissue Banking, 2019 - Springer
The well-characterized curative effect of transplanted mesenchymal stem cells has been
mainly attributed to their homing and subsequent differentiation for the repair and …